Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :21257746
Publication Date : //

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.


Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to bind ADP-ribose derivatives, which diverged through evolution to support many different protein functions and pathways. The observation that some sirtuins and macrodomains are physically linked as fusion proteins or genetically coupled through the same operon, provided a clue that their functions might be connected. Indeed, here we demonstrate that the product of the sirtuin reaction OAADPr is a substrate for several related macrodomain proteins: human MacroD1, human MacroD2, Escherichia coli YmdB, and the sirtuin-linked MacroD-like protein from Staphylococcus aureus. In addition, we show that the cell extracts derived from MacroD-deficient Neurospora crassa strain exhibit a major reduction in the ability to hydrolyze OAADPr. Our data support a novel function of macrodomains as OAADPr deacetylases and potential in vivo regulators of cellular OAADPr produced by NAD(+)-dependent deacetylation.

Authors : Chen Dawei , Vollmar Melanie , Rossi Marianna N , Phillips Claire , Kraehenbuehl Rolf , Slade Dea , Mehrotra Pawan V , von Delft Frank , Crosthwaite Susan K , Gileadi Opher , Denu John M , Ahel Ivan ,

Related products :

Catalog number Product name Quantity
OARD1_HUMAN Human ELISA Kit FOR O-acetyl-ADP-ribose deacetylase 1 96T
E0769h Bovine ELISA Kit FOR O-acetyl-ADP-ribose deacetylase 1 96T
P5CS_HUMAN Bovine ELISA Kit FOR O-acetyl-ADP-ribose deacetylase 1 96T
M84976313 5-deoxy-1’2’3’-tri-o-acetyl-beta-D-ribose CAS: [62211-93-2] 100 mg
CF130_HUMAN Human ELISA Kit FOR O-acetyl-ADP-ribose deacetylase C6orf130 96T
A164255 1-O-Acetyl-3,5-bis(4-chlorobenzoyl)-2-deoxy-D-ribose C21H18Cl2O7 CAS: 1207459-15-1 500 mg
18-003-43136 ADP-ribose pyrophosphatase. mitochondrial - EC 3.6.1.13; ADP-ribose diphosphatase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase; ADP-ribose phosphohydrolase; Nucleoside diphosphate-linked moi 0.05 mg Aff Pur
EIAAB28259 Adenosine diphosphoribose pyrophosphatase,ADP-ribose diphosphatase,ADP-ribose phosphohydrolase,ADP-ribose pyrophosphatase, mitochondrial,ADPR-PPase,Mouse,Mus musculus,Nucleoside diphosphate-linked moi
EIAAB28258 Adenosine diphosphoribose pyrophosphatase,ADP-ribose diphosphatase,ADP-ribose phosphohydrolase,ADP-ribose pyrophosphatase, mitochondrial,ADPR-PPase,Homo sapiens,Human,Nucleoside diphosphate-linked moi
EIAAB28257 Adenosine diphosphoribose pyrophosphatase,ADP-ribose diphosphatase,ADP-ribose phosphohydrolase,ADP-ribose pyrophosphatase, mitochondrial,ADPR-PPase,Nucleoside diphosphate-linked moiety X motif 9,Nudix
EIAAB06938 C6orf130,Homo sapiens,Human,O-acetyl-ADP-ribose deacetylase C6orf130
18265-46-8 Ribose-5-monophosphoric acid disodium Ribose-5-monophosph 1g
XGC-BiRDS-ChipSeq12 Bioinformatics analysis of ChipSeq data for identification of binding sites for DNA-associated proteins Upto 12 samples
34980-65-9 a-D-Ribose-5-phosphate a-D-Ribose-5-phosphat 1g
B1088 Kligler Iron Agar,Modified USE For identification of Yersinia enterocolitica.Also used for differential identification of gram_negative enteric bacilli on the basis of fermentation of dextrose, lact Qty per Litre of Medium: 57,3
B1088 Kligler Iron Agar,Modified USE For identification of Yersinia enterocolitica.Also used for differential identification of gram_negative enteric bacilli on the basis of fermentation of dextrose, lact Qty per Litre of Medium: 57,3
25-160 TIPARP is a poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation 0.05 mg
B1088 Kligler Iron Agar,Modified USE : For identification of Yersinia enterocolitica.Also used for differential identification of gram-negative enteric bacilli on the basis of fermentation of dextrose, lact 5x500gm
B891 Listeria Identification Agar Base (PALCAM) USE For selective isolation and identification of Listeria species. Qty per Litre of Medium: 69
B098 Listeria Identification Broth Base (PALCAM) USE For selective isolation and identification of Listeria species. Qty per Litre of Medium: 47,4
B1132 Listeria Identification Agar (PALCAM), Modified USE For selective isolation and identification of Listeria species. Qty per Litre of Medium: 71,88
TM 1226 LISTERIA IDENTIFICATION AGAR BASE (PALCAM) (for selective isolation and identification of Listeria species) 500 gm
TM 1226 LISTERIA IDENTIFICATION AGAR BASE (PALCAM) (for selective isolation and identification of Listeria species) 100 gm
B891 Listeria Identification Agar Base (PALCAM) USE : For selective isolation and identification of Listeria species. 5x500gm
B098 Listeria Identification Broth Base (PALCAM) USE : For selective isolation and identification of Listeria species. 5x500gm


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur