Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :23784779
Publication Date : //

Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.


Directional cell migration is a fundamental process in neural development. In Caenorhabditis elegans, Q neuroblasts on the left (QL) and right (QR) sides of the animal generate cells that migrate in opposite directions along the anteroposterior body axis. The homeobox (Hox) gene lin-39 promotes the anterior migration of QR descendants (QR.x), whereas the canonical Wnt signaling pathway activates another Hox gene, mab-5, to ensure the QL descendants' (QL.x) posterior migration. However, the regulatory targets of LIN-39 and MAB-5 remain elusive. Here, we showed that MIG-13, an evolutionarily conserved transmembrane protein, cell-autonomously regulates the asymmetric distribution of the actin cytoskeleton in the leading migratory edge. We identified mig-13 as a cellular target of LIN-39 and MAB-5. LIN-39 establishes QR.x anterior polarity by binding to the mig-13 promoter and promoting mig-13 expression, whereas MAB-5 inhibits QL.x anterior polarity by associating with the lin-39 promoter and downregulating lin-39 and mig-13 expression. Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration.

Authors : Wang Xiangming , Zhou Fanli , Lv Sijing , Yi Peishan , Zhu Zhiwen , Yang Yihong , Feng Guoxin , Li Wei , Ou Guangshuo ,

Related products :

Catalog number Product name Quantity
25-019 CMTM2 belongs to the chemokine-like factor superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein may play an important role in 0.05 mg
SKA2_BOVIN Rat ELISA Kit FOR NMDA receptor synaptonuclear signaling and neuronal migration factor 96T
E0121h Rat ELISA Kit FOR NMDA receptor synaptonuclear signaling and neuronal migration factor 96T
CSRP2_HUMAN Rat ELISA Kit FOR NMDA receptor synaptonuclear signaling and neuronal migration factor 96T
25-499 HMG20A plays a role in neuronal differentiation as chromatin-associated protein. It overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes 0.05 mg
27-813 SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses. 0.1 mg
27-164 ARHGAPs, such as ARHGAP25, are negative regulators of Rho GTPases, which are implicated in actin remodeling, cell polarity, and cell migration.ARHGAPs, such as ARHGAP25, encode negative regulators of 0.05 mg
28-098 RRN3 is RNA polymerase I-specific transcription initiation factor. Phosphorylation of RRN3 by MAPK cascades links cell signaling with the control of gene expression, namely results in rRNA synthesis i 0.05 mg
CL-1001 Signaling Cell Gene Expression: Real-Time PCR Assay for Monitoring NFkB Regulated Genes
CSB-EL006576RA Rat Neuronal migration protein doublecortin(DCX) ELISA kit 96T
EIAAB38520 Rat,Rattus norvegicus,SHP2-interacting transmembrane adapter protein,Signaling threshold-regulating transmembrane adapter 1,Sit,Sit1,Suppression-inducing transmembrane adapter 1
EIAAB38519 Mouse,Mus musculus,SHP2-interacting transmembrane adapter protein,Signaling threshold-regulating transmembrane adapter 1,Sit,Sit1,Suppression-inducing transmembrane adapter 1
CSB-EL006576MO Mouse Neuronal migration protein doublecortin(DCX) ELISA kit 96T
DCX_HUMAN Human ELISA Kit FOR Neuronal migration protein doublecortin 96T
EIAAB10687 Dcx,Neuronal migration protein doublecortin,Rat,Rattus norvegicus
CSB-EL006576RA Rat Neuronal migration protein doublecortin(DCX) ELISA kit SpeciesRat 96T
DCX_MOUSE Mouse ELISA Kit FOR Neuronal migration protein doublecortin 96T
CSB-EL006576HU Human Neuronal migration protein doublecortin(DCX) ELISA kit 96T
EIAAB38518 gp30_40,Homo sapiens,Human,SHP2-interacting transmembrane adapter protein,Signaling threshold-regulating transmembrane adapter 1,SIT,SIT1,Suppression-inducing transmembrane adapter 1
CSB-EL006576MO Mouse Neuronal migration protein doublecortin(DCX) ELISA kit SpeciesMouse 96T
CSB-EL006576HU Human Neuronal migration protein doublecortin(DCX) ELISA kit SpeciesHuman 96T
DCX_RAT ELISA Kit FOR Neuronal migration protein doublecortin; organism: Rat; gene name: Dcx 96T
EIAAB10688 Dcn,Dcx,Doublin,Lissencephalin-X,Lis-X,Mouse,Mus musculus,Neuronal migration protein doublecortin
DCX_MOUSE ELISA Kit FOR Neuronal migration protein doublecortin; organism: Mouse; gene name: Dcx 96T
26-040 The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch protein family are transmembrane receptors that are critica 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur