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Pubmed ID :27193680
Publication Date : //

Structure of the T4 baseplate and its function in triggering sheath contraction.


Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell membranes. This macromolecular machine resembles a stretched, coiled spring (or sheath) wound around a rigid tube with a spike-shaped protein at its tip. A baseplate structure, which is arguably the most complex part of this assembly, relays the contraction signal to the sheath. Here we present the atomic structure of the approximately 6-megadalton bacteriophage T4 baseplate in its pre- and post-host attachment states and explain the events that lead to sheath contraction in atomic detail. We establish the identity and function of a minimal set of components that is conserved in all contractile injection systems and show that the triggering mechanism is universally conserved.

Authors : Taylor Nicholas M I , Prokhorov Nikolai S , Guerrero-Ferreira Ricardo C , Shneider Mikhail M , Browning Christopher , Goldie Kenneth N , Stahlberg Henning , Leiman Petr G ,

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