Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :3053705
Publication Date : //

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.


Amyloid deposits occurring in the islets of Langerhans in patients with noninsulin-dependent diabetes mellitus and some insulinomas contain a 37-amino acid peptide that is structurally related to calcitonin gene-related peptide. We have identified three cDNA clones encoding islet amyloid polypeptide (IAPP) or diabetes-associated peptide (DAP) by oligonucleotide screening of a lambda gt10 human insulinoma cDNA library. Two of the three cDNAs contained a domain encoding IAPP/DAP but had an intron-like sequence in their 5' region. The other cDNA contained an open reading frame encoding an 89-amino acid precursor having a typical signal peptide followed by a small prohormone-like sequence containing within it the IAPP/DAP peptide bracketed at its NH2 and COOH termini by Lys-Arg and Gly-Lys-Arg, respectively. These data indicate that this amyloid peptide is generated by proteolytic processing similar to that for proinsulin and other islet prohormones and also that the peptide may be carboxyamidated. The isolation of cDNA clones having 5'-unprocessed intron-like sequences suggests that inefficient or alternative splicing of this mRNA occurred in the insulinoma.

Authors : Sanke T , Bell G I , Sample C , Rubenstein A H , Steiner D F ,

Related products :

Catalog number Product name Quantity
orb60003 beta Amyloid Beta-amyloid 1-42 is known as a biomarker of manifest AD that is detectable in cerebrospinal fluid (CSF). It is the 42-amino acid fragment of amyloid precursor protein. For research use o 1 mg
30-797 APPBP2 interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and_or processing. The beta-amyloid precursor protein is a cell surface protein with sig 0.05 mg
18-272-197032 Amyloid Precursor Protein - Goat polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 P 0.05 ml
18-272-197028 Amyloid Precursor Protein - Rabbit polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 0.1 mg
18-272-196327 Amyloid Precursor Protein - Rabbit polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 0.5 ml
18-272-195346 Amyloid Precursor Protein - Rabbit polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 0.05 ml
18-272-197027 Amyloid Precursor Protein - Rabbit polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 0.1 mg
18-272-195345 Amyloid Precursor Protein - Rabbit polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 0.05 ml
18-272-197033 Amyloid Precursor Protein - Goat polyclonal to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; PreA4 P 0.05 ml
20-272-190769 Amyloid Precursor Protein - Mouse monoclonal [3E9] to Amyloid Precursor Protein; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; APPI; 0.05 mg
18-272-196328 Amyloid Precursor Protein prediluted - Rabbit polyclonal to Amyloid Precursor Protein prediluted; APP; ABPP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; Protease nexin- 7 ml
27-491 PCSK6 is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. This gene is thought to play a role in tumor progression. 0.1 mg
E0812h ELISA Amylin,DAP,Diabetes-associated peptide,Homo sapiens,Human,IAPP,Insulinoma amyloid peptide,Islet amyloid polypeptide 96T
U0812h CLIA Amylin,DAP,Diabetes-associated peptide,Homo sapiens,Human,IAPP,Insulinoma amyloid peptide,Islet amyloid polypeptide 96T
E0812h ELISA kit Amylin,DAP,Diabetes-associated peptide,Homo sapiens,Human,IAPP,Insulinoma amyloid peptide,Islet amyloid polypeptide 96T
32-113 Amyloid precursor protein(APP) ,with 32-amino acid protein (about 35 kDa), is part of a super-family of transmembrane and secreted proteins. It appears to have a number of roles, including regulation 0.1 mL
E0409r ELISA kit Pancreatitis-associated protein 1,Pap,Pap1,Peptide 23,Rat,Rattus norvegicus,Reg III-beta,Reg2,REG-2,Reg3b,REG-3-beta,Regenerating islet-derived protein 3-beta,Regenerating islet-derived pro 96T
orb72137 Amyloid Precursor Protein peptide This is Amyloid Precursor Protein peptide. For research use only. 1 mg
orb72133 Amyloid Precursor Protein peptide This is Amyloid Precursor Protein peptide. For research use only. 1 mg
U0409r CLIA Pancreatitis-associated protein 1,Pap,Pap1,Peptide 23,Rat,Rattus norvegicus,Reg III-beta,Reg2,REG-2,Reg3b,REG-3-beta,Regenerating islet-derived protein 3-beta,Regenerating islet-derived protein I 96T
E0409r ELISA Pancreatitis-associated protein 1,Pap,Pap1,Peptide 23,Rat,Rattus norvegicus,Reg III-beta,Reg2,REG-2,Reg3b,REG-3-beta,Regenerating islet-derived protein 3-beta,Regenerating islet-derived protein 96T
orb71293 beta Amyloid Protein Precursor 770 (135-155) peptide This is beta Amyloid Protein Precursor 770 (135-155) peptide. For research use only. 1 mg
orb71292 beta Amyloid Protein Precursor (657-676) peptide This is beta Amyloid Protein Precursor (657-676) peptide. For research use only. 1 mg
PEP-HT31P-001 Kinase inhibitors: PKA anchoring inhibitor Ht31P (n.b.), peptide, CAS number: , Chemical name: 23 amino acid peptide derived from Ht31 (negative control peptide) 1 mg
31-364 PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur