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An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.
Amyloid deposits occurring in the islets of Langerhans in patients with noninsulin-dependent diabetes mellitus and some insulinomas contain a 37-amino acid peptide that is structurally related to calcitonin gene-related peptide. We have identified three cDNA clones encoding islet amyloid polypeptide (IAPP) or diabetes-associated peptide (DAP) by oligonucleotide screening of a lambda gt10 human insulinoma cDNA library. Two of the three cDNAs contained a domain encoding IAPP/DAP but had an intron-like sequence in their 5' region. The other cDNA contained an open reading frame encoding an 89-amino acid precursor having a typical signal peptide followed by a small prohormone-like sequence containing within it the IAPP/DAP peptide bracketed at its NH2 and COOH termini by Lys-Arg and Gly-Lys-Arg, respectively. These data indicate that this amyloid peptide is generated by proteolytic processing similar to that for proinsulin and other islet prohormones and also that the peptide may be carboxyamidated. The isolation of cDNA clones having 5'-unprocessed intron-like sequences suggests that inefficient or alternative splicing of this mRNA occurred in the insulinoma.
Authors : Sanke T , Bell G I , Sample C , Rubenstein A H , Steiner D F ,
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Pathways :
WP1008: amino acid conjugation of benzoic acid
WP1127: amino acid conjugation of benzoic acid
WP1252: amino acid conjugation of benzoic acid
WP1287: amino acid conjugation of benzoic acid
WP1577: amino acid conjugation of benzoic acid
WP1621: Arginine and proline metabolism
WP521: amino acid conjugation of benzoic acid
WP662: Amino Acid metabolism
WP7: Sulfur Amino Acid biosynthesis
WP715: amino acid conjugation
WP891: amino acid conjugation of benzoic acid
WP1001: Peptide GPCRs
WP1020: Fatty Acid Biosynthesis
WP1023: mRNA processing
WP105: Fatty Acid Beta Oxidation 2
WP1061: Fatty Acid Beta Oxidation
WP1075: Folic Acid Network
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1117: Peptide GPCRs
WP1139: Fatty Acid Biosynthesis
WP1142: mRNA processing
WP1177: Fatty Acid Beta Oxidation
WP1192: Folic Acid Network
WP1207: Fatty Acid Beta Oxidation
WP121: Colanic Acid Building Blocks Biosynthesis
Related Genes :
[AN DOQ At1g01510 F22L4.6] C-terminal binding protein AN (CtBP) (Protein ANGUSTIFOLIA) (Protein DETORQUEO)
[TIR1 FBL1 WEI1 At3g62980 T20O10.80] Protein TRANSPORT INHIBITOR RESPONSE 1 (Weak ethylene-insensitive protein 1)
[core C PC-C pre-c preC PreC/C preC/C prec/C HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[nuoC nuoCD nuoD b2286 JW5375] NADH-quinone oxidoreductase subunit C/D (EC 1.6.5.11) (NADH dehydrogenase I subunit C/D) (NDH-1 subunit C/D) (NUO3/NUO4)
[] Hydroxycinnamoyl-CoA hydratase-lyase (HCHL) (EC 4.1.2.41) (EC 4.2.1.101) (P-hydroxycinnamoyl CoA hydratase/lyase) (Trans-feruloyl-CoA hydratase/vanillin synthase)
[Cspg4 An2 Kiaa4232 Ng2] Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Proteoglycan AN2)
[] Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[AN8327] Endopolygalacturonase AN8327 (EC 3.2.1.15) (Pectinase AN8327) (Polygalacturonase AN8327)
[cysG XNC1_3857] Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (Uroporphyrinogen III methylase) (UROM) (SUMT); Precorrin-2 dehydrogenase (EC 1.3.1.76); Sirohydrochlorin ferrochelatase (EC 4.99.1.4)]
[ppnP AN672_12185 AN688_0223300 AN690_0224925 AZ002_002797 AZ006_003347 AZ013_002763 BED30_04270 BED45_00540 CES93_20070 CFA70_10315 CQW88_04225 HMPREF3212_04465 TO64_11015] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[Or46a AN8 AN9 dor19 DOR46F DOR46F.1 Or46b OR46F Or46F.1 Or46F.2 CG33478] Odorant receptor 46a, isoform B
[glmU XNC1_0023] Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]
[S preS1 preS2 HBVgp2] Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen)
[PAX6 AN2] Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin)
[pan3 AN0769 AN10121/AN10119] PAN2-PAN3 deadenylation complex subunit pan3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)
[Zfand5 Za20d2 Zfp216 Znf216] AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)
[Or22a AN11 DOR22A.1 dor53 Or22A.1 CG12193] Odorant receptor 22a
[Or46a AN8 AN9 dor19 DOR46F DOR46F.1 Or46b OR46F Or46F.1 Or46F.2 CG33478] Odorant receptor 46a, isoform A
[mcsA AN6650] 2-methylcitrate synthase, mitochondrial (Methylcitrate synthase) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase 2) (EC 2.3.3.16)
[orsA AN7909] Orsellinic acid synthase (OAS) (EC 2.3.1.-) (Non-reducing polyketide synthase orsA) (Orsellinic acid/F9775 biosynthesis cluster protein A)
[Or22b AN12 DOR22A.2 dor67 Or22A.2 CG4231] Odorant receptor 22b
[myoA AN1558] Myosin-1 (Class I unconventional myosin) (Type I myosin)
[fadB XNC1_3875] Fatty acid oxidation complex subunit alpha [Includes: 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35); Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase (EC 4.2.1.17) (EC 5.1.2.3) (EC 5.3.3.8)]
[brlA AN0973] C2H2 type master regulator of conidiophore development brlA (Bristle A protein)
[DCAF7 HAN11 WDR68] DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog)
[aromA aroA aroM AN0708] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]
[nudA AN0118] Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)
[nimA AN9504] G2-specific protein kinase nimA (EC 2.7.11.1) (Never in mitosis)
[bimG AN0410] Serine/threonine-protein phosphatase PP1 (EC 3.1.3.16)
[mdpG AN0150] Atrochrysone carboxylic acid synthase (ACAS) (EC 2.3.1.-) (Monodictyphenone synthesis protein G) (Non-reducing polyketide synthase mdpG)
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