Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :7542942
Publication Date : //

The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs.


The heterodimeric protein SRP9/14 bound to the Alu sequences of SRP RNA is essential for the translational control function of the signal recognition particle (SRP). The Alu RNAs of primate cells are believed to be derived from SRP RNA and have been shown to bind to an SRP14-related protein in vitro. We have used antibodies to characterize SRP9/14 and examine its association with small RNAs in vivo. Although SRP9 proteins are the same size in both rodent and primate cells, SRP14 subunits are generally larger in primate cells. An additional alanine-rich domain at the C-terminus accounts for the larger size of one human isoform. Although the other four SRP proteins are largely assembled into SRP in both rodent and primate cells, we found that the heterodimer SRP9/14 is present in 20-fold excess over SRP in primate cells. An increased synthesis rate of both proteins may contribute to their accumulation. The majority of the excess SRP9/14 is cytoplasmic and does not appear to be bound to any small RNAs; however, a significant fraction of a small cytoplasmic Alu RNA is complexed with SRP9/14 in a 8.5 S particle. Our findings that there is a large excess of SRP9/14 in primate cells and that Alu RNAs are bound to SRP9/14 in vivo suggest that this heterodimeric protein may play additional roles in the translational control of gene expression and/or Alu transcript metabolism.

Authors : Bovia F , Fornallaz M , Leffers H , Strub K ,

Related products :

Catalog number Product name Quantity
EIAAB39894 Mouse,Mus musculus,Signal recognition particle 9 kDa protein,SRP9,Srp9
EIAAB39895 Homo sapiens,Human,Signal recognition particle 9 kDa protein,SRP9,SRP9
SRP9 SRP9 Gene signal recognition particle 9kDa
E02S0185 Rat Signal Recognition Particle 9kDa Elisa Kit (SRP9) 96 Tests/kit
H0896 Signal recognition particle 9 kDa protein (SRP9), Dog, ELISA Kit 96T
CSB-EL022680DO Dog Signal recognition particle 9 kDa protein(SRP9) ELISA kit 96T
E02S0185 Rat Signal Recognition Particle 9kDa ELISA , SRP9
201-20-5575 SRP9{signal recognition particle 9kDa}rabbit.pAb 0.2ml
E02S0185 Rat Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
H2988 SRP9 (Signal Recognition Particle 9kDa), Pig, ELISA Kit 96T
E03S0185 Mouse Signal Recognition Particle 9kDa ELISA , SRP9
E13S0185 Anserine Signal Recognition Particle 9kDa Elisa Kit (SRP9) 96 Tests/kit
E09S0185 Monkey Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
E04S0185 Rabbit Signal Recognition Particle 9kDa ELISA , SRP9
CSB-EL022680DO Dog Signal recognition particle 9 kDa protein(SRP9) ELISA kit SpeciesDog 96T
E12S0185 Chicken Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
E05S0185 Guinea pig Signal Recognition Particle 9kDa ELISA , SRP9
H2984 SRP9 (Signal Recognition Particle 9kDa), Chicken, ELISA Kit 96T
H2985 SRP9 (Signal Recognition Particle 9kDa), Guinea Pig, ELISA Kit 96T
E06S0185 Goat Signal Recognition Particle 9kDa ELISA , SRP9
E01S0185 Human Signal Recognition Particle 9kDa ELISA , SRP9
E01S0185 Human Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
E07S0185 Porcine Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
E11S0185 Bovine Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit
E06S0185 Goat Signal Recognition Particle 9kDa ELISA , SRP9 96 Tests/kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur