Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :8752209
Publication Date : //

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.


The MAD-related (MADR) family of proteins are essential components in the signaling pathways of serine/threonine kinase receptors for the transforming growth factor beta (TGFbeta) superfamily. We demonstrate that MADR2 is specifically regulated by TGFbeta and not bone morphogenetic proteins. The gene for MADR2 was found to reside on chromosome 18q21, near DPC4, another MADR protein implicated in pancreatic cancer. Mutational analysis of MADR2 in sporadic tumors identified four missense mutations in colorectal carcinomas, two of which display a loss of heterozygosity. Biochemical and functional analysis of three of these demonstrates that the mutations are inactivating. These findings suggest that MADR2 is a tumor suppressor and that mutations acquired in colorectal carcinomas may function to disrupt TGFbeta signaling.

Authors : Eppert K , Scherer S W , Ozcelik H , Pirone R , Hoodless P , Kim H , Tsui L C , Bapat B , Gallinger S , Andrulis I L , Thomsen G H , Wrana J L , Attisano L ,

Related products :

Catalog number Product name Quantity
28-476 AKAP7 encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and ta 0.1 mg
EIAAB27645 Homo sapiens,Human,Nasopharyngeal carcinoma down-regulated gene protein 1,Nasopharyngeal carcinoma-related gene protein,NPCDR1,NPCDRG,NPCR
20-272-191778 colorectal carcinoma _ CD3 - Mouse monoclonal [BS-1] to colorectal carcinoma _ CD3 Monoclonal 0.25 mg
20-272-191759 Colorectal Carcinoma - Mouse monoclonal [Y94] to Colorectal Carcinoma Monoclonal 0.25 mg
MCCC2 MCC Gene mutated in colorectal cancers
201-20-3294 MCC{mutated in colorectal cancers}rabbit.pAb 0.2ml
GS-1287a mutated in colorectal cancers primary antibody, Host: Rabbit 200ul
Dcc-1718M Protein: Recombinant Mouse Deleted In Colorectal Carcinoma 50ug
Dcc-1718M Protein Recombinant Mouse Deleted In Colorectal Carcinoma 50ug
EIAAB39771 Colorectal carcinoma-associated protein,Homo sapiens,Human,KIAA1840,Spastic paraplegia 11 protein,Spatacsin,SPG11
KITpD816V/RP1MG Human recombinant proteins: CKIT mutated site point mutated, KIT partial (754a.a. - 875a.a.) sequence lenght mutated recombinant protein with GST 1MG
KITpD816V/RP100 Human recombinant proteins: CKIT mutated site point mutated, KIT partial (754a.a. - 875a.a.) sequence lenght mutated recombinant protein with GST 100
KITpD816V/RP10 Human recombinant proteins: CKIT mutated site point mutated, KIT partial (754a.a. - 875a.a.) sequence lenght mutated recombinant protein with GST 10
KITpD816V/RP50 Human recombinant proteins: CKIT mutated site point mutated, KIT partial (754a.a. - 875a.a.) sequence lenght mutated recombinant protein with GST 50
933 Colorectal carcinoma and matched adjacent normal tissue array with lymph node metastasis carcinoma, including TNM and pathology grade, 64 cases_100 cores, replacing CO1002
28-035 BRD2 encodes a mitogen-activated kinase which localizes to the nucleus. BRD2 maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests th 0.05 mg
26-897 The gene that encodes ARCN1 maps in a region, which includes the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur 0.05 mg
CO1002b Colorectal carcinoma and matched adjacent normal tissue array with lymph node metastasis carcinoma, including TNM and pathology grade, 64 cases_100 cores, replacing CO1002
CO1002b Colorectal carcinoma and matched adjacent normal tissue array with lymph node metastasis carcinoma, including TNM and pathology grade, 64 cases_100 cores, replacing CO1002
30-653 CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. CIP29 appears to be a new cytokine regulated protein involved in normal and cancer cell pro 0.05 mg
30-487 Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon 0.05 mg
31-235 MBP-1 encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. Th 0.05 mg
CO1002b Colorectal carcinoma and matched adjacent normal tissue array with lymph node metastasis carcinoma, including TNM and pathology grade, 64 cases_100 cores, replacing CO1002; ihc Anti-Actin confirmed
28-069 ENO1 encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. The 0.05 mg
CSB-EL013571HU Human mutated in colorectal cancers (MCC) ELISA kit, Species Human, Sample Type serum, plasma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur