GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
p50csk is a tyrosine protein kinase (TPK) that represses the activity of Src family TPKs. We previously showed that Csk is a potent negative regulator of antigen receptor signaling in T lymphocytes and that its Src homology (SH) 3 and SH2 domains are required to inhibit these signals. To test the idea that the Csk SH3 and SH2 domains mediate interactions with other cellular proteins, we attempted to identify Csk-associated polypeptides using the yeast two-hybrid system. The results of our experiments demonstrated that Csk physically associates with PEP, a protein tyrosine phosphatase (PTP) expressed in hemopoietic cells. Further analyses revealed that this interaction was mediated by the Csk SH3 domain and by a proline-rich region (PPPLPERTP) in the non-catalytic C-terminal portion of PEP. The association between Csk and PEP was documented in transiently transfected Cos-1 cells and in a variety of cells of hemopoietic lineages, including T cells. Additional analyses demonstrated that the association between Csk and PEP is highly specific. Together, these data indicated that PEP may be an effector and/or a regulator of p50csk in T cells and other hemopoietic cells. Moreover, they allowed the identification of PEP as the first known ligand for the Csk SH3 domain.
Authors : Cloutier J F , Veillette A ,
Related products :
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
info@gentaur.com | Gentaur
GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur
GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
RCS Paris B 484 237 888
SIRET 48423788800017
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
france@gentaur.com | Gentaur
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur
GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U
GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur
ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX 058 710 33 48
poland@gentaur.com | Gentaur
Other countries
Österreich +43720880899
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Danmark +4569918806
Finland Helsset +358942419041
Magyarország Budapest +3619980547
Ireland Dublin+35316526556
Luxembourg+35220880274
Norge Oslo+4721031366
Sverige Stockholm+46852503438
Schweiz Züri+41435006251
US New York+17185132983
GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur
Pathways :
WP1714: Tyrosine metabolism
WP1493: Carbon assimilation C4 pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP120: Phenylalanine and Tyrosine Biosynthesis
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1603: Nicotine Activity on Chromaffin Cells
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
Related Genes :
[igf2bp3-a vera-a vickz3-a] Insulin-like growth factor 2 mRNA-binding protein 3-A (IGF2 mRNA-binding protein 3-A) (IMP-3-A) (69 kDa RNA-binding protein A) (IGF-II mRNA-binding protein 3-A) (KH domain-containing transcription factor B3-A) (RNA-binding protein Vera-A) (Trans-acting factor B3-A) (VICKZ family member 3-A) (VLE-binding protein A) (Vg1 RNA-binding protein A) (Vg1 RBP-A) (Vg1 localization element binding protein A) (VgLE-binding and ER association protein A)
[Rassf5 Nore1 Rapl] Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
[] RNA1 polyprotein (P1) [Cleaved into: Protein X1; Protein X2; Putative ATP-dependent helicase (EC 3.6.4.-) (Membrane-binding protein) (NTP-binding protein) (NTB); Viral genome-linked protein (VPg); Picornain 3C-like protease (3C-like protease) (PRO) (EC 3.4.22.-); RNA-directed RNA polymerase (POL) (EC 2.7.7.48)]
[RASSF1 RDA32] Ras association domain-containing protein 1
[RASSF5 NORE1 RAPL] Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)
[igf2bp3-b vickz3-b] Insulin-like growth factor 2 mRNA-binding protein 3-B (IGF2 mRNA-binding protein 3-B) (IMP-3-B) (69 kDa RNA-binding protein B) (B3.65 protein B) (IGF-II mRNA-binding protein 3-B) (KH domain-containing transcription factor B3-B) (RNA-binding protein Vera-B) (Trans-acting factor B3-B) (VICKZ family member 3-B) (VLE-binding protein B) (Vg1 RNA-binding protein B) (Vg1 RBP-B) (Vg1 localization element binding protein B) (VgLE-binding and ER association protein B)
[Rassf2 Kiaa0168] Ras association domain-containing protein 2
[NBDY LINC01420] Negative regulator of P-body association (P-body dissociating protein) (Protein NoBody)
[STM1 MPT4 STO1 YLR150W L9634.1] Suppressor protein STM1 (3BP1) (GU4 nucleic-binding protein 2) (G4p2 protein) (POP2 multicopy suppressor protein 4) (Ribosomal subunits association factor) (AF) (TOM1 suppressor protein 1) (Triplex-binding protein 1)
[RASSF2 CENP-34 KIAA0168] Ras association domain-containing protein 2
[Rassf9 Pamci Pcip1] Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)
[RASSF7 C11orf13 HRC1] Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)
[Rassf1] Ras association domain-containing protein 1 (Protein 123F2)
[ratA pasT yfjG b2619 JW2600] Ribosome association toxin RatA (Toxin RatA)
[RIN2 RASSF4] Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)
[RASSF6] Ras association domain-containing protein 6
[RASSF3] Ras association domain-containing protein 3
[RASSF4 AD037] Ras association domain-containing protein 4
[RASSF9 PAMCI PCIP1] Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)
[Rassf2] Ras association domain-containing protein 2
[Rassf5 Nore1] Ras association domain-containing protein 5 (Maxp1) (New ras effector 1)
[RASSF8 C12orf2] Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)
[Rassf6] Ras association domain-containing protein 6
[pasT ratA yfjG c3141] Persistence and stress-resistance toxin PasT (Ribosome association toxin RatA)
[RASSF10] Ras association domain-containing protein 10
[Rassf4] Ras association domain-containing protein 4
[] RNA2 polyprotein (P2) [Cleaved into: Protein 2A; Movement protein (MP); Coat protein (CP)]
[Rassf9 Pamci Pcip1] Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)
[RASSF2] Ras association domain family member 2 (Ras association domain-containing protein 2)
[RASSF2 CK820_G0017519] RASSF2 isoform 1 (RASSF2 isoform 3) (Ras association (RalGDS/AF-6) domain family member 2) (Ras association domain family member 2)
Bibliography :
No related Items
Enter catalog number :
Favorites Pages:
No Favorits