Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :9688283
Publication Date : //

Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor.


The human osteoprotegerin (OPG)-osteoclastogenesis-inhibitory factor (OCIF) gene has been cloned and characterized. The OPG-OCIF gene is a single-copy gene consisting of five exons, and spans 29 kb of the human genome. All the exon/intron boundaries comply with the GT/AG rule. The translation-termination codon is present in exon 5 and a typical poly(A)-addition signal resides 173-nucleotides downstream of the translation-termination codon. A major transcription-initiation site is present 67-nucleotides upstream of the initiation ATG codon. Two minor sites are present further upstream. The 4.2-kb and 6.5-kb transcripts detected in IMR-90 cells were found to contain the 3'-half of intron 2 and the entire intron 2, respectively. In the OPG-OCIF gene, a single intron divides the stretch that encode four Cys-rich motifs, implying diversity from the other members of the tumor necrosis factor receptor (TNFR) family. Two death domain homologous regions (DDHs) present in tandem in OPG-OCIF are encoded separately by exons 4 and 5. The conservation of amino-acid sequences suggests that exon 4 is produced by a duplication of a portion of exon 5.

Authors : Morinaga T , Nakagawa N , Yasuda H , Tsuda E , Higashio K ,

Related products :

Catalog number Product name Quantity
E0108h ELISA Homo sapiens,Human,OCIF,OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B 96T
E0108h ELISA kit Homo sapiens,Human,OCIF,OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B 96T
U0108h CLIA Homo sapiens,Human,OCIF,OPG,Osteoclastogenesis inhibitory factor,Osteoprotegerin,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B 96T
18-003-42866 Tumor necrosis factor receptor superfamily member 11B - Osteoprotegerin; Osteoclastogenesis inhibitory factor Polyclonal 0.1 mg Protein A
E0108m ELISA kit Mouse,Mus musculus,Ocif,Opg,Osteoclastogenesis inhibitory factor,Osteoprotegerin,Tnfrsf11b,Tumor necrosis factor receptor superfamily member 11B 96T
U0108m CLIA Mouse,Mus musculus,Ocif,Opg,Osteoclastogenesis inhibitory factor,Osteoprotegerin,Tnfrsf11b,Tumor necrosis factor receptor superfamily member 11B 96T
E0108m ELISA Mouse,Mus musculus,Ocif,Opg,Osteoclastogenesis inhibitory factor,Osteoprotegerin,Tnfrsf11b,Tumor necrosis factor receptor superfamily member 11B 96T
gen2817 TR11B_HUMAN Osteoclastogenesis inhibitory factor ELISA tesk kit 1
gen2823 TR11B_MOUSE Osteoclastogenesis inhibitory factor ELISA tesk kit 1
FYC005-20P T&A™ Cloning Kit + ECOS™ 101 (DH5α) Gene Cloning Products FYC001-20P + FYE607-10VL x 2
FYC006-20P T&A™ Cloning Kit + ECOS™ 9-5 (JM109) Gene Cloning Products FYC001-20P + FYE707-10VL x 2
FYC002-20P T&A™ Cloning Vector Gene Cloning Products *cloning vector (20 rxns), 25 ng/μl, 40 μl *control insert DNA, 10 ng/μl, 10 μl
FYC001-20P T&A™ Cloning Kits Gene Cloning Products *cloning vector (20 rxns), 25 ng/μl, 40 μl *control insert DNA, 10 ng/μl, 10 μl *T4 ligase, 2 U/μl
orb80516 Human Leukemia Inhibitory Factor protein Leukemia Inhibitory Factor (LIF) Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 180 amino acids and having a 2
28-974 This gene was identified based on its homology to the gene encoding the RING3 protein, a serine_threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility c 0.1 mg
25-204 BRD3 gene was identified based on its homology to the gene encoding the RING3 protein, a serine_threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility c 0.05 mg
26-395 The gene encoding PCDHA5 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization sim 0.05 mg
MIG7 MIF Gene macrophage migration inhibitory factor (glycosylation-inhibiting factor)
LIG1 LIF Gene leukemia inhibitory factor (cholinergic differentiation factor)
IC-1006 pEco-T7-cHis PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells, for E Coli expression of C-term His-tagged protein. 10 x 50ul/ea
IC-1001 pEco-T7-nHis PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells for E Coli expression of N-term His-tagged protein. 10 x 50ul/ea
IC-1004 pEco-T7-nGST PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells for E Coli expression of N-term GST-tagged protein. 10 x 50ul/ea
U2034h CLIA kit GDF15,GDF-15,Growth_differentiation factor 15,Homo sapiens,Human,Macrophage inhibitory cytokine 1,MIC1,MIC-1,NAG-1,NRG-1,NSAID-activated gene 1 protein,NSAID-regulated gene 1 protein,PDF,PLA 96T
E2034h ELISA kit GDF15,GDF-15,Growth_differentiation factor 15,Homo sapiens,Human,Macrophage inhibitory cytokine 1,MIC1,MIC-1,NAG-1,NRG-1,NSAID-activated gene 1 protein,NSAID-regulated gene 1 protein,PDF,PL 96T
U2034h CLIA GDF15,GDF-15,Growth_differentiation factor 15,Homo sapiens,Human,Macrophage inhibitory cytokine 1,MIC1,MIC-1,NAG-1,NRG-1,NSAID-activated gene 1 protein,NSAID-regulated gene 1 protein,PDF,PLAB,Pla 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur