Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :10025408
Publication Date : //

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.


Activation of the type I TGFbeta receptor (TbetaR-I) requires phosphorylation of a regulatory segment known as the GS region, located upstream of the serine/threonine kinase domain in the cytoplasmic portion of the receptor. The crystal structure of a fragment of unphosphorylated TbetaR-I, containing both the GS region and the catalytic domain, has been determined in complex with the FK506-binding protein FKBP12. TbetaR-I adopts an inactive conformation that is maintained by the unphosphorylated GS region. FKBP12 binds to the GS region of the receptor, capping the TbetaR-II phosphorylation sites and further stabilizing the inactive conformation of TbetaR-I. Certain structural features at the catalytic center of TbetaR-I are characteristic of tyrosine kinases rather than Ser/Thr kinases.

Authors : Huse M , Chen Y G , Massagué J , Kuriyan J ,

Related products :

Catalog number Product name Quantity
27-174 KLHL15 is a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac_poxvirus and zinc finger domain and C-ter 0.05 mg
30-879 IL13RA2 is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a 0.05 mg
EIAAB42165 Homo sapiens,Human,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42158 Rat,Rattus norvegicus,Serine_threonine-protein kinase receptor R4,SKR4,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,Tgfbr1,TGFR-1,Transforming growth factor-beta
EIAAB42163 Rat,Rattus norvegicus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42164 Mouse,Mus musculus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42157 Bos taurus,Bovine,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42156 Pig,Sus scrofa,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42162 Pig,Sus scrofa,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
26-279 IL28RA belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three 0.05 mg
30-351 IL28RA belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three 0.05 mg
30-880 IL13RA2 is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. IL13RA2 binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signa 0.05 mg
CSB-EL020994MO Mouse sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (SEMA5A) ELISA kit, Species Mouse, Sample Type serum, 96T
CSB-EL020994HU Human sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (SEMA5A) ELISA kit, Species Human, Sample Type serum, 96T
CSB-EL020995MO Mouse sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B (SEMA5B) ELISA kit, Species Mouse, Sample Type serum, 96T
CSB-EL020995HU Human sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B (SEMA5B) ELISA kit, Species Human, Sample Type serum, 96T
CSB-EL020992RA Rat sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F (SEMA4F) ELISA kit, Species Rat, Sample Type serum, plasma 96T
EIAAB42161 Chicken,Gallus gallus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
129-10417 Rabbit Anti-Human Lectin-type Oxidized LDL Receptor (LOX-1) _ OLR1 (Cytoplasmic Domain) 100
SEMA5A SEMA5A Gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA5B SEMA5B Gene sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
EIAAB42159 ESK2,Mouse,Mus musculus,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,Tgfbr1,TGFR-1,Transforming growth factor-beta receptor type I
CSB-EL020997RA Rat sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B (SEMA6B) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL020998RA Rat sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C (SEMA6C) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL020993MO Mouse sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (SEMA4G) ELISA kit, Species Mouse, Sample Type serum, plasma 96T


https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/

 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur

RSS Feeds · Most Popular · Today's Favorites · All Time Favorites · Gentaur Policy
© Copyright 2010-2011 GENTAUR molecular products.