Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :10397733
Publication Date : //

The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.


The Tat protein of human immunodeficiency virus type-1 (HIV-1) has been shown to be released during acute infection of T cells by HIV-1 and to promote angiogenesis and Kaposi's sarcoma (KS) development in infected individuals. In this study, we investigated the molecular mechanisms responsible for the angiogenic effects of Tat. The results shown herein indicate that two different Tat domains cooperate to induce these effects by different pathways. The arginine-glycine-aspartic acid (RGD) sequence present at the carboxyterminal of Tat mediates vascular cell migration and invasion by binding to the alpha5beta1 and alphavbeta3 integrins. This interaction also provides endothelial cells with the adhesion signal they require to grow in response to mitogens. At the same time, the Tat basic sequence retrieves into a soluble form extracellular basic fibroblast growth factor (bFGF) bound to heparan sulfate proteoglycans by competing for heparin-binding sites. This soluble bFGF mediates Tat-induced vascular cell growth. These effects resemble those of extracellular matrix proteins, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules.

Authors : Barillari G , Sgadari C , Fiorelli V , Samaniego F , Colombini S , Manzari V , Modesti A , Nair B C , Cafaro A , Stürzl M , Ensoli B ,

Related products :

Catalog number Product name Quantity
10-271-82072 Fibroblast Growth Factor-basic Human - HBGF-2; Basic fibroblast growth factor; BFGF; Prostatropin 0.05 mg
10-271-82072 Fibroblast Growth Factor-basic Human - HBGF-2; Basic fibroblast growth factor; BFGF; Prostatropin 0.01 mg
orb82697 Human FGF basic protein Firbroblast Growth Factor 2 (basic) (FGF2) is a member of the fibroblast growth factor(FGF) family. FGF family members bind heparin and possess broad mitogenic andangiogenic ac 1 mg
20-271-80050 Vascular Endothelial Cell Growth Factor - Mouse Anti Human Vascular Endothelial Cell Growth Factor; VEGF-A; Vascular permeability factor; VPF Monoclonal 0.5 mg
20-271-80050 Vascular Endothelial Cell Growth Factor - Mouse Anti Human Vascular Endothelial Cell Growth Factor; VEGF-A; Vascular permeability factor; VPF Monoclonal 1 mg
300-001 FGF-2 (basic) Human Host: E. coli FGF2; BFGF; FGFB; HBGF-2; basic Fibroblast growth factor (bFGF); Heparin binding growth factor-2 10
300-002 FGF-2 (basic) Human Host: E. coli FGF2; BFGF; FGFB; HBGF-2; basic Fibroblast growth factor (bFGF); Heparin binding growth factor-2 25
300-003 FGF-2 (basic) Human Host: E. coli FGF2; BFGF; FGFB; HBGF-2; basic Fibroblast growth factor (bFGF); Heparin binding growth factor-2 50
MO-C40046F Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG1,k, Clone Number F-474 0.5 mg
MO-C40046H Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG1,k, Clone Number F-3 0.5 mg
MO-C40046I Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG1,k, Clone Number F-198 0.5 mg
MO-C40046B Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG2a,k, Clone Number F-74 0.5 mg
MO-C40046E Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG1,k, Clone Number F-216 0.5 mg
MO-C40046A Monoclonal Antibodies to Cytokines and Growth Factors Fibroblast Growth Factor - Basic (bFGF), anti-human, Format Aff. pur., Host Mouse, ISO Type IgG1,k, Clone Number F-343 0.5 mg
20-663-48024 Vascular Endothelial Cell Growth Factor (mAHuVEGF) - Mouse Anti-Human Vascular Endothelial Cell Growth Factor (mAHuVEGF); VEGF-A; Vascular permeability factor; VPF Monoclonal 0.5 mg
20-663-48024 Vascular Endothelial Cell Growth Factor (mAHuVEGF) - Mouse Anti-Human Vascular Endothelial Cell Growth Factor (mAHuVEGF); VEGF-A; Vascular permeability factor; VPF Monoclonal 1 mg
orb82038 Human FGF-basic, recombinant protein Fibroblast Growth Factor-basic (FGF-basic) Recombinant is a purified cytokine_growth factor. For research use only. 50
10-663-45195 Glycosylated Fibroblast Growth Factor-acidic Human - HBGF-1; Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF-beta N_A 0.01 mg
10-663-45195 Glycosylated Fibroblast Growth Factor-acidic Human - HBGF-1; Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF-beta N_A 1 mg
10-663-45195 Glycosylated Fibroblast Growth Factor-acidic Human - HBGF-1; Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF-beta N_A 0.002 mg
cyt-365 Recombinant Human Fibroblast Growth Factor-basic Sf9 CYTOKINES AND GROWTH FACTORS 1mg
cyt-557 Recombinant Human Fibroblast Growth Factor-basic (147 a.a) CYTOKINES AND GROWTH FACTORS 50
cyt-218 Recombinant Human Fibroblast Growth Factor-basic CYTOKINES AND GROWTH FACTORS 1mg
cyt-365 Recombinant Human Fibroblast Growth Factor-basic Sf9 CYTOKINES AND GROWTH FACTORS 10
cyt-218 Recombinant Human Fibroblast Growth Factor-basic CYTOKINES AND GROWTH FACTORS 50


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur