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Pubmed ID :10421844
Publication Date : 1999/10/14

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.


TRAF6, a member of the tumour necrosis factor receptor-associated factor family, was first identified as a transducer of CD40 and interleukin-1 receptor (IL-1R) signals based on the interaction of TRAF6 with the cytoplasmic tail of CD40 and with the IL-1R associated kinase in vitro. However, the functions of TRAF6 in vivo remain unidentified.

Authors : Naito A , Azuma S , Tanaka S , Miyazaki T , Takaki S , Takatsu K , Nakao K , Nakamura K , Katsuki M , Yamamoto T , Inoue J ,

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