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Pubmed ID :10426995
Publication Date : //

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.


The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for many pathogens, the molecules that induce IL-12 production by macrophages and the mechanisms by which they do so remain undefined. Here it is shown that microbial lipoproteins are potent stimulators of IL-12 production by human macrophages, and that induction is mediated by Toll-like receptors (TLRs). Several lipoproteins stimulated TLR-dependent transcription of inducible nitric oxide synthase and the production of nitric oxide, a powerful microbicidal pathway. Activation of TLRs by microbial lipoproteins may initiate innate defense mechanisms against infectious pathogens.

Authors : Brightbill H D , Libraty D H , Krutzik S R , Yang R B , Belisle J T , Bleharski J R , Maitland M , Norgard M V , Plevy S E , Smale S T , Brennan P J , Bloom B R , Godowski P J , Modlin R L ,

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