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Smads are signal transducers for the members of the transforming growth factor-beta (TGF-beta) superfamily. Bone morphogenetic proteins (BMPs) and their receptors induce differentiation of C2C12 cells into osteoblast-like cells. Using an adenoviral expression vector system, we showed that receptor-regulated Smads (R-Smads) activated by BMPs can induce the differentiation of C2C12 cells. Inhibitory Smads (I-Smads) interfere with the osteoblast differentiation of C2C12 cells by preventing the nuclear translocation of R-Smads. After translocation into the nucleus, Smad oligomers regulate the transcription of target genes through binding to DNA directly, interaction with other DNA binding proteins, and recruitment of transcriptional co-activators or co-repressors. Through interaction with different transcription factors and transcriptional co-activators or co-repressors, Smads may exhibit specific effects in various cell types.
Authors : Miyazono K ,
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WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP113: TGF Beta Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1224: EBV LMP1 signaling
WP1367: TGF-beta Receptor Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP1434: Osteopontin Signaling
WP1571: EBV LMP1 signaling
WP1835: Interferon alpha/beta signaling
WP210: Cytoplasmic Ribosomal Proteins
WP230: TGF Beta Signaling Pathway
WP244: Alpha 6 Beta 4 signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP262: EBV LMP1 signaling
WP362: TGF-beta Receptor Signaling Pathway
WP366: TGF beta Signaling Pathway
WP505: TGF Beta Signaling Pathway
WP560: TGF Beta Signaling Pathway
WP809: TGF-beta Receptor Signaling Pathway
WP812: TGF Beta Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP930: TGF Beta Signaling Pathway
WP10: IL-9 Signaling Pathway
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