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Cells of Escherichia coli growing on sugars that result in catabolite repression or amino acids that feed into glycolysis undergo a metabolic switch associated with the production and utilization of acetate. As they divide exponentially, these cells excrete acetate via the phosphotransacetylase-acetate kinase pathway. As they begin the transition to stationary phase, they instead resorb acetate, activate it to acetyl coenzyme A (acetyl-CoA) by means of the enzyme acetyl-CoA synthetase (Acs) and utilize it to generate energy and biosynthetic components via the tricarboxylic acid cycle and the glyoxylate shunt, respectively. Here, we present evidence that this switch occurs primarily through the induction of acs and that the timing and magnitude of this induction depend, in part, on the direct action of the carbon regulator cyclic AMP receptor protein (CRP) and the oxygen regulator FNR. It also depends, probably indirectly, upon the glyoxylate shunt repressor IclR, its activator FadR, and many enzymes involved in acetate metabolism. On the basis of these results, we propose that cells induce acs, and thus their ability to assimilate acetate, in response to rising cyclic AMP levels, falling oxygen partial pressure, and the flux of carbon through acetate-associated pathways.
Authors : Kumari S , Beatty C M , Browning D F , Busby S J , Simel E J , Hovel-Miner G , Wolfe A J ,
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WP2272: Pathogenic Escherichia coli infection
WP1708: Terpenoid backbone biosynthesis
WP1019: FAS pathway and Stress induction of HSP regulation
WP1043: Calcium Regulation in the Cardiac Cell
WP1062: Regulation of Actin Cytoskeleton
WP1111: Prostaglandin Synthesis and Regulation
WP1138: FAS pathway and Stress induction of HSP regulation
WP1159: Calcium Regulation in the Cardiac Cell
WP1178: Regulation of Actin Cytoskeleton
WP1365: Calcium Regulation in the Cardiac Cell
WP1380: Regulation of Actin Cytoskeleton
WP1425: BMP signalling and regulation
WP1449: Regulation of toll-like receptor signaling pathway
WP1530: miRNA regulation of DNA Damage Response
WP1577: amino acid conjugation of benzoic acid
WP1578: BMP signalling and regulation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1648: Fatty acid metabolism
WP1690: Propanoate metabolism
WP1695: Pyruvate metabolism
WP1706: Synthesis and degradation of ketone bodies
WP1712: Tryptophan metabolism
WP1713: Two-component system
WP1717: Valine, leucine and isoleucine degradation
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