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Pubmed ID :11024028
Publication Date : //

Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals.


Ammonium transporters play a key functional role in nitrogen uptake and assimilation in microorganisms and plants; however, little is known about their structural counterpart in mammals. Here, we report the molecular cloning and biochemical characterization of Rh type B glycoproteins, human RhBG and mouse Rhbg, two new members of the Rh family with distinct tissue specificities. The RhBG orthologues possess a conserved 12-transmembrane topology and most resemble bacterial and archaeal ammonium transporters. Human RHBG resides at chromosome 1q21.3, which harbors candidate genes for medullary cystic kidney disease, whereas mouse Rhbg is syntenic on chromosome 3. Northern blot and in situ hybridization revealed that RHBG and Rhbg are predominantly expressed in liver, kidney, and skin, the specialized organs involving ammonia genesis, excretion, or secretion. Confocal microscopy showed that RhBG is located in the plasma membrane and in some intracellular granules. Western blots of membrane proteins from stable HEK293 cells and from mouse kidney and liver confirmed this distribution. N-Glycanase digestion showed that RhBG/Rhbg has a carbohydrate moiety probably attached at the NHS motif on exoloop 1. Phylogenetic clustering, tissue-specific expression, and plasma membrane location suggest that RhBG homologous proteins are the long sought major ammonium transporters in mammalians.

Authors : Liu Z , Peng J , Mo R , Hui C , Huang C H ,

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EIAAB34629 Ammonium transporter Rh type C,C15orf6,CDRC2,Homo sapiens,Human,PDRC2,Rh family type C glycoprotein,Rh glycoprotein kidney,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein,RHG
EIAAB34594 Ammonium transporter Rh type A,Bos taurus,Bovine,Erythrocyte membrane glycoprotein Rh50,Rh family type A glycoprotein,Rh type A glycoprotein,RH50,RHAG,Rhesus blood group family type A glycoprotein
EIAAB34597 Ammonium transporter Rh type A,Erythrocyte membrane glycoprotein Rh50,Mouse,Mus musculus,Rh family type A glycoprotein,Rh type A glycoprotein,Rh50,Rhag,Rhesus blood group family type A glycoprotein
EIAAB34596 Ammonium transporter Rh type A,Erythrocyte membrane glycoprotein Rh50,Rat,Rattus norvegicus,Rh family type A glycoprotein,Rh type A glycoprotein,Rh50,Rhag,Rhesus blood group family type A glycoprotein
EIAAB34608 Ammonium transporter Rh type B,Homo sapiens,Human,Rh family type B glycoprotein,Rh type B glycoprotein,RHBG,Rhesus blood group family type B glycoprotein
EIAAB34610 Ammonium transporter Rh type B,Oryctolagus cuniculus,Rabbit,Rh family type B glycoprotein,Rh type B glycoprotein,RHBG,Rhesus blood group family type B glycoprotein
EIAAB34630 Ammonium transporter Rh type C,Oryctolagus cuniculus,Rabbit,Rh family type C glycoprotein,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein
EIAAB34631 Ammonium transporter Rh type C,Bos taurus,Bovine,Rh family type C glycoprotein,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein
EIAAB34628 Ammonium transporter Rh type C,Rat,Rattus norvegicus,Rh family type C glycoprotein,Rh type C glycoprotein,Rhcg,Rhesus blood group family type C glycoprotein
EIAAB34607 Ammonium transporter Rh type B,Bos taurus,Bovine,Rh family type B glycoprotein,Rh type B glycoprotein,RHBG,Rhesus blood group family type B glycoprotein
EIAAB34609 Ammonium transporter Rh type B,Mouse,Mus musculus,Rh family type B glycoprotein,Rh type B glycoprotein,Rhbg,Rhesus blood group family type B glycoprotein
EIAAB34606 Ammonium transporter Rh type B,Rat,Rattus norvegicus,Rh family type B glycoprotein,Rh type B glycoprotein,Rhbg,Rhesus blood group family type B glycoprotein
EIAAB34627 Ammonium transporter Rh type C,Pig,Rh family type C glycoprotein,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein,Sus scrofa
EIAAB34612 Ammonium transporter Rh type B,Pig,Rh family type B glycoprotein,Rh type B glycoprotein,RHBG,Rhesus blood group family type B glycoprotein,Sus scrofa
EIAAB34595 Ammonium transporter Rh type A,Erythrocyte membrane glycoprotein Rh50,Erythrocyte plasma membrane 50 kDa glycoprotein,Homo sapiens,Human,Rh family type A glycoprotein,Rh type A glycoprotein,RH50,Rh50A
EIAAB34634 Ammonium transporter Rh type C,Chicken,Gallus gallus,Rh family type C glycoprotein,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein
EIAAB41109 Homo sapiens,Human,Putative taste receptor type 2 member 12,Putative taste receptor type 2 member 26,T2R12,T2R26,TAS2R12,TAS2R26
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EIAAB34633 Ammonium transporter Rh type C,Canis familiaris,Canis lupus familiaris,Dog,Rh family type C glycoprotein,Rh type C glycoprotein,RHCG,Rhesus blood group family type C glycoprotein
EIAAB34611 Ammonium transporter Rh type B,Canis familiaris,Canis lupus familiaris,Dog,Rh family type B glycoprotein,Rh type B glycoprotein,RHBG,Rhesus blood group family type B glycoprotein
EIAAB34593 Ammonium transporter Rh type A,Canis familiaris,Canis lupus familiaris,Dog,Erythrocyte membrane glycoprotein Rh50,Rh family type A glycoprotein,Rh type A glycoprotein,RHAG,Rhesus blood group family ty
EIAAB43290 Glycoprotein Gp34,Homo sapiens,Human,OX40 ligand,OX40L,TAX transcriptionally-activated glycoprotein 1,TNFSF4,Tumor necrosis factor ligand superfamily member 4,TXGP1
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EIAAB07746 Beta-glucan receptor,Bgr,Clec7a,Clecsf12,C-type lectin domain family 7 member A,C-type lectin superfamily member 12,DC-associated C-type lectin 1,Dectin1,Dectin-1,Dendritic cell-associated C-type lect
EIAAB07747 Beta-glucan receptor,BGR,CLEC7A,CLECSF12,C-type lectin domain family 7 member A,C-type lectin superfamily member 12,DC-associated C-type lectin 1,DECTIN1,Dectin-1,Dendritic cell-associated C-type lect


 

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