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Pubmed ID :11435115
Publication Date : //

Structural characterization of the LEM motif common to three human inner nuclear membrane proteins.


Integral membrane proteins of the inner nuclear membrane are involved in chromatin organization and postmitotic reassembly of the nucleus. The discovery that mutations in the gene encoding emerin causes X-linked Emery-Dreifuss muscular dystrophy has enhanced interest in such proteins. A common structural domain of 50 residues, called the LEM domain, has been identified in emerin MAN1, and lamina-associated polypeptide (LAP) 2. In particular, all LAP2 isoforms share an N-terminal segment composed of such a LEM domain that is connected to a highly divergent LEM-like domain by a linker that is probably unstructured.

Authors : Laguri C , Gilquin B , Wolff N , Romi-Lebrun R , Courchay K , Callebaut I , Worman H J , Zinn-Justin S ,

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