Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11493458
Publication Date : 2001/08/08

Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface.


It is demonstrated that similar to interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha) induces coordinated changes at different steps of the major histocompatibility complex (MHC) class I processing and presentation pathway in nonprofessional antigen-presenting cells (APCs). TNF-alpha up-regulates the expression of 3 catalytic immunoproteasome subunits--LMP2, LMP7, and MECL-1--the immunomodulatory proteasome activator PA28 alpha, the TAP1/TAP2 heterodimer, and the total pool of MHC class I heavy chain. It was also found that in TNF-alpha--treated cells, MHC class I molecules reconstitute more rapidly and have an increased average half-life at the cell surface. Biochemical changes induced by TNF-alpha in the MHC class I pathway were translated into increased sensitivity of TNF-alpha--treated targets to lysis by CD8(+) cytotoxic T cells, demonstrating improved presentation of at least certain endogenously processed MHC class I--restricted peptide epitopes. Significantly, it was demonstrated that the effects of TNF-alpha observed in this experimental system were not mediated through the induction of IFN-gamma. It appears to be likely that TNF-alpha--mediated effects on MHC class I processing and presentation do not involve any intermediate messengers. Collectively, these data demonstrate the existence of yet another biologic activity exerted by TNF-alpha, namely its capacity to act as a coordinated multi-step modulator of the MHC class I pathway of antigen processing and presentation. These results suggest that TNF-alpha may be useful when a concerted up-regulation of the MHC class I presentation machinery is required but cannot be achieved by IFN-gamma. (Blood. 2001;98:1108-1115)

Authors : Hallermalm K , Seki K , Wei C , Castelli C , Rivoltini L , Kiessling R , Levitskaya J ,

Related products :

Catalog number Product name Quantity
E0910h ELISA kit Class I histocompatibility antigen-like protein,Homo sapiens,Human,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,MR1 96T
U0910m CLIA Class I histocompatibility antigen-like protein,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,Mouse,Mr1,Mr1a,Mus musculus 96T
E0910m ELISA kit Class I histocompatibility antigen-like protein,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,Mouse,Mr1,Mr1a,Mus musculus 96T
E0910h ELISA Class I histocompatibility antigen-like protein,Homo sapiens,Human,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,MR1 96T
U0910h CLIA Class I histocompatibility antigen-like protein,Homo sapiens,Human,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,MR1 96T
E0910m ELISA Class I histocompatibility antigen-like protein,Major histocompatibility complex class I-related gene protein,MHC class I-related gene protein,Mouse,Mr1,Mr1a,Mus musculus 96T
20-321-175075 MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II - MONOCLONAL ANTIBODY TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II Monoclonal 0.1 mg
HLA-DOA HLA-DMA Gene major histocompatibility complex, class II, DM alpha
RPR-535 Recombinant Human Major Histocompatibility Complex Class II DO Alpha 5
HLA-DRB3 HLA-DRA Gene major histocompatibility complex, class II, DR alpha
HLA-DPA1 HLA-DOA Gene major histocompatibility complex, class II, DO alpha
201-20-2551 HLA-DRA{major histocompatibility complex, class II, DR alpha}rabbit.pAb 0.2ml
201-20-2547 HLA-DMA{major histocompatibility complex, class II, DM alpha}rabbit.pAb 0.2ml
pro-1535 Recombinant Human Major Histocompatibility Complex Class II DO Alpha 20
HLA-DQA1 HLA-DPA1 Gene major histocompatibility complex, class II, DP alpha 1
pro-1535 Recombinant Human Major Histocompatibility Complex Class II DO Alpha 1mg
201-20-2549 HLA-DQA2{major histocompatibility complex, class II, DQ alpha 2}rabbit.pAb 0.2ml
201-20-2548 HLA-DPA1{major histocompatibility complex, class II, DP alpha 1}rabbit.pAb 0.2ml
HLA-DQB1 HLA-DQA1 Gene major histocompatibility complex, class II, DQ alpha 1
HLA-DQB2 HLA-DQA2 Gene major histocompatibility complex, class II, DQ alpha 2
pro-1535 Recombinant Human Major Histocompatibility Complex Class II DO Alpha 5
CSB-EL010493HU Human major histocompatibility complex, class II, DQ alpha 2 (HLA-DQA2) ELISA kit 96T
EIAAB11726 DP(W3),DP(W4),HLA class II histocompatibility antigen, DP alpha 1 chain,HLA-DP1A,HLA-DPA1,HLASB,HLA-SB alpha chain,Homo sapiens,Human,MHC class II DP3-alpha,MHC class II DPA1
EIAAB11884 DX alpha chain,HLA class II histocompatibility antigen, DQ alpha 2 chain,HLA class II histocompatibility antigen, DQ(6) alpha chain,HLA-DQA1,HLA-DQA2,HLA-DXA,Homo sapiens,Human,MHC class II DQA2
GS-0975a major histocompatibility complex, class II, DM alpha primary antibody, Host: Rabbit 200ul


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur