Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Five peroxiredoxin genes have been identified in Drosophila melanogaster on the basis of a genome-wide search. Three of the genes (DPx-4156, DPx-4783, and DPx-5037) fall into the 2-Cys subgroup, while the other two (DPx-2540 and DPx-6005) belong to the 1-Cys subgroup. Using cDNAs, all five were expressed in E. coli and the purified recombinant proteins were shown to reduce H(2)O(2) in the presence of dithiothreitol. The three 2-Cys Prx were also shown to be active in the thioredoxin system and were, consequently, classified as thioredoxin peroxidases. Antisera raised against the DPx-4783 recombinant protein crossreacted with all family members and recognized protein species of the predicted sizes (22-27 kD). All five family members, when individually overexpressed in Drosophila S2 cells, conferred some resistance to H(2)O(2) treatment, as measured by cell viability. Functional diversification of the Drosophila peroxiredoxin family members was suggested by two lines of evidence: (i) the patterns of mRNA accumulation varied for the different genes during development and (ii) recombinant proteins fused to an epitope tag and overexpressed in Drosophila cells, differed in subcellular localizations--three proteins occurred in the cytosol, one was localized to the mitochondria, and one was found to be secreted.
Authors : Radyuk S N , Klichko V I , Spinola B , Sohal R S , Orr W C ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
email@example.com | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP1012: IL-7 Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1031: IL-3 Signaling Pathway
WP1052: Id Signaling Pathway
WP1055: IL-4 signaling Pathway
WP1131: IL-7 Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1150: IL-3 Signaling Pathway
WP1168: Id Signaling Pathway
WP1171: IL-4 signaling Pathway
WP118: IL-7 Signaling Pathway
WP1263: Mitochondrial Gene Expression
WP1301: Mitochondrial Gene Expression
WP1346: IL-7 Signaling Pathway
WP1359: IL-3 Signaling Pathway
WP1368: Mitochondrial Gene Expression
WP1374: Id Signaling Pathway
WP1376: IL-4 signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1485: Interactions between CFTR and other ion channels
WP1545: miRNAs involved in DDR
WP1780: ABC-family proteins mediated transport
WP1799: Costimulation by the CD28 family
WP182: IL-4 Signaling Pathway
WP1821: Gene Expression
Related Genes :
 Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.
 Molecular cloning, expression analysis and characterization of peroxiredoxin during WSSV infection in shrimp Fenneropenaeus indicus.
 Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila.
 Genes of the antioxidant system of the honey bee: annotation and phylogeny.
 Molecular cloning and characterization of a peroxiredoxin gene from the mole cricket, Gryllotalpa orientalis.
 Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells.
 The peroxiredoxin gene family in Drosophila melanogaster.
 Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila.
Enter catalog number :