Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11685249
Publication Date : //

A novel, specific interaction involving the Csk SH3 domain and its natural ligand.


C-terminal Src kinase (Csk) takes part in a highly specific, high affinity interaction via its Src homology 3 (SH3) domain with the proline-enriched tyrosine phosphatase PEP in hematopoietic cells. The solution structure of the Csk-SH3 domain in complex with a 25-residue peptide from the Pro/Glu/Ser/Thr-rich (PEST) domain of PEP reveals the basis for this specific peptide recognition motif involving an SH3 domain. Three residues, Ala 40, Thr 42 and Lys 43, in the SH3 domain of Csk specifically recognize two hydrophobic residues, Ile 625 and Val 626, in the proline-rich sequence of the PEST domain of PEP. These two residues are C-terminal to the conventional proline-rich SH3 domain recognition sequence of PEP. This interaction is required in addition to the classic polyproline helix (PPII) recognition by the Csk-SH3 domain for the association between Csk and PEP in vivo. NMR relaxation analysis suggests that Csk-SH3 has different dynamic properties in the various subsites important for peptide recognition.

Authors : Ghose R , Shekhtman A , Goger M J , Ji H , Cowburn D ,

Related products :

Catalog number Product name Quantity
30-623 SPRY3 contains 1 B30.2_SPRY domain. Sprouty_Caveolin-1 interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner. Spry 1, 2 and 3 expression was observed in placental tis 0.05 mg
30-834 DYX1C1contains 1 CS domain and 3 TPR repeats. A chromosomal aberration, translocation t (2;15) (q11;q21), involving DYX1C1 may be a cause of dyslexia. 0.05 mg
26-657 DYX1C1contains 1 CS domain and 3 TPR repeats. A chromosomal aberration, translocation t (2;15) (q11;q21), involving DYX1C1 may be a cause of dyslexia. 0.05 mg
25-529 ZNF335 enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear horm 0.05 mg
25-305 The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation.The PR domain is a protei 0.05 mg
27-237 TLX1 contains 1 homeobox DNA-binding domain. TLX1 controls the genesis of the spleen. A chromosomal aberration involving TLX1, translocation t (10;14) (q24;q11) with TCRD, may be a cause of a form of 0.05 mg
27-332 LYL1 contains 1 basic helix-loop-helix (bHLH) domain. A chromosomal aberration, translocation t (7;19) (q35;p13) with TCRB, involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukem 0.05 mg
orb71023 SH2 Domain Ligand 1 peptide This is SH2 Domain Ligand 1 peptide. For research use only. 1 mg
orb71968 SH2 Domain Ligand 3 peptide This is SH2 Domain Ligand 3 peptide. For research use only. 1 mg
orb71025 SH2 Domain Ligand 4 peptide This is SH2 Domain Ligand 4 peptide. For research use only. 1 mg
orb71024 SH2 Domain Ligand 2 peptide This is SH2 Domain Ligand 2 peptide. For research use only. 1 mg
orb71026 SH2 Domain Ligand 5 peptide This is SH2 Domain Ligand 5 peptide. For research use only. 1 mg
30-043 Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine_th 0.05 mg
30-044 Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine_th 0.05 mg
26-522 ARID3C is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patter 0.05 mg
pro-620 Recombinant Human Stromal Interaction Molecule 1 RECOMBINANT & NATURAL PROTEINS 1mg
pro-620 Recombinant Human Stromal Interaction Molecule 1 RECOMBINANT & NATURAL PROTEINS 25
pro-620 Recombinant Human Stromal Interaction Molecule 1 RECOMBINANT & NATURAL PROTEINS 5
pro-1115 Recombinant HumanVesicle Transport Through Interaction with t-SNAREs Homolog 1B RECOMBINANT & NATURAL PROTEINS 2
pro-1115 Recombinant HumanVesicle Transport Through Interaction with t-SNAREs Homolog 1B RECOMBINANT & NATURAL PROTEINS 100
pro-1115 Recombinant HumanVesicle Transport Through Interaction with t-SNAREs Homolog 1B RECOMBINANT & NATURAL PROTEINS 10
N1I1 VDR-LBD. Purified GST-tagged human Vitamin D receptor ligand binding domain. Applications: Ligand-binding and coregulator displacement assays. 50 ug
N1H4 FXR-LBD. Purified GST-tagged human Farnesoid X receptor ligand binding domain. Applications: Ligand-binding and coregulator displacement assays. 50 ug
N1H2 LXRB-LBD. Purified GST-tagged human Liver X receptor beta ligand binding domain. Applications: Ligand-binding and coregulator displacement assays. 50 ug
N1H3 LXRA-LBD. Purified GST-tagged human Liver X receptor alpha ligand binding domain. Applications: Ligand-binding and coregulator displacement assays. 50 ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur