Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :11847341
Publication Date : //

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.


Phosphorylation of mitogen-activated protein kinases (MAPKs) on specific tyrosine and threonine sites by MAP kinase kinases (MAPKKs) is thought to be the sole activation mechanism. Here, we report an unexpected activation mechanism for p38alpha MAPK that does not involve the prototypic kinase cascade. Rather it depends on interaction of p38alpha with TAB1 [transforming growth factor-beta-activated protein kinase 1 (TAK1)-binding protein 1] leading to autophosphorylation and activation of p38alpha. We detected formation of a TRAF6-TAB1-p38alpha complex and showed stimulus-specific TAB1-dependent and TAB1-independent p38alpha activation. These findings suggest that alternative activation pathways contribute to the biological responses of p38alpha to various stimuli.

Authors : Ge Baoxue , Gram Hermann , Di Padova Franco , Huang Betty , New Liguo , Ulevitch Richard J , Luo Ying , Han Jiahuai ,

Related products :

Catalog number Product name Quantity
7756-5 p38alpha, Active 5 μg
7756-5 Active p38alpha 5 μg
7756-5 p38alpha, Active 5 ìg
7756-5 Active p38alpha 5 ug
PR-328 p38alpha per SAPK2aHis - inactive 20
PR-327 p38alpha per SAPK2aHis - active 20
PE-210 P38alpha substrate peptide 1mg
7756-5 p38alpha, Active proteins 5 μg
7756-5 Active p38alpha MAPK14 5 μg
PE-210 P38alpha substrate peptide RRRLVEPLTPSGEAPNQK 1mg
PE-210 P38alpha substrate peptide RRRLVEPLTPSGEAPNQK 1 mg
56450 Anti-p38alpha MAP Kinase 100ug
PE-210 Proteins: P38alpha substrate peptide RRRLVEPLTPSGEAPNQK 1mg
56450 Anti-p38alpha MAP Kinase Monoclonal 100ug
A025360 Rabbit Anti-p38MAPK per MAPK14 per p38Alpha Ab 100ul
40070 p38alpha Active Human Recombinant Protein 10
40070 p38alpha Active Human Recombinant Protein 10 µg
PR-328 p38alpha per SAPK2aHis, inactive Stress-activated protein kinase human, recombinant, E. coli 20
PR-327 p38alpha per SAPK2aHis, active Stress-activated protein kinase human, recombinant, E. coli 20
28-652 Yaf2 binds to MYC and inhibits MYC-mediated transactivation. Yaf2 also binds to MYCN and enhances MYCN-dependent transcriptional activation. Yaf2 increases calpain 2-mediated proteolysis of YY1 in vit 0.05 mg
orb60466 LY2228820 LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38alpha MAPK and p38betaMAPK were 7 nM and 3 nM, respectively). For research use only. 10 mg
28-103 The TRIM41 gene encodes a protein observed in the cytoplasm and the nucleus. Nuclear transport is mediated by an N-terminal segment common to both alpha and beta isoforms, but independent of a classic 0.05 mg
25-235 The TRIM41 gene encodes a protein observed in the cytoplasm and the nucleus. Nuclear transport is mediated by an N-terminal segment common to both alpha and beta isoforms, but independent of a classic 0.05 mg
30-561 TRAF3IP3 may function as an adapter molecule that regulates TRAF3-mediated JNK activation. 0.05 mg
27-585 MAP3K7IP2 is an activator of MAP3K7_TAK1, which is required for for the IL-1 induced activation of NF. B and MAPK8_JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serving as 0.05 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur