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Pubmed ID :11859360
Publication Date : //

The genome sequence of Schizosaccharomyces pombe.


We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.

Authors : Wood V , Gwilliam R , Rajandream M-A , Lyne M , Lyne R , Stewart A , Sgouros J , Peat N , Hayles J , Baker S , Basham D , Bowman S , Brooks K , Brown D , Brown S , Chillingworth T , Churcher C , Collins M , Connor R , Cronin A , Davis P , Feltwell T , Fraser A , Gentles S , Goble A , Hamlin N , Harris D , Hidalgo J , Hodgson G , Holroyd S , Hornsby T , Howarth S , Huckle E J , Hunt S , Jagels K , James K , Jones L , Jones M , Leather S , McDonald S , McLean J , Mooney P , Moule S , Mungall K , Murphy L , Niblett D , Odell C , Oliver K , O'Neil S , Pearson D , Quail M A , Rabbinowitsch E , Rutherford K , Rutter S , Saunders D , Seeger K , Sharp S , Skelton J , Simmonds M , Squares R , Squares S , Stevens K , Taylor K , Taylor R G , Tivey A , Walsh S , Warren T , Whitehead S , Woodward J , Volckaert G , Aert R , Robben J , Grymonprez B , Weltjens I , Vanstreels E , Rieger M , Schäfer M , Müller-Auer S , Gabel C , Fuchs M , Düsterhöft A , Fritzc C , Holzer E , Moestl D , Hilbert H , Borzym K , Langer I , Beck A , Lehrach H , Reinhardt R , Pohl T M , Eger P , Zimmermann W , Wedler H , Wambutt R , Purnelle B , Goffeau A , Cadieu E , Dréano S , Gloux S , Lelaure V , Mottier S , Galibert F , Aves S J , Xiang Z , Hunt C , Moore K , Hurst S M , Lucas M , Rochet M , Gaillardin C , Tallada V A , Garzon A , Thode G , Daga R R , Cruzado L , Jimenez J , Sánchez M , del Rey F , Benito J , Domínguez A , Revuelta J L , Moreno S , Armstrong J , Forsburg S L , Cerutti L , Lowe T , McCombie W R , Paulsen I , Potashkin J , Shpakovski G V , Ussery D , Barrell B G , Nurse P , Cerrutti L ,

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Catalog number Product name Quantity
63-004 anti_Rad22(S.pombe)antibody, rabbit serum Rad22 protein of Schizosaccharomyces pombe (fission yeast) is a functional and structural homolog of S. cerevisiae and human Rad52 proteins, which play a majo 250 ul
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63-153 anti_Mrc1 (S. pombe) antibody rabbit antiserum Mrc1 (Mediator of replication checkpoint is as S_phase checkpoint protein of Schizosaccharomyces pombe found at replication forks. It is required for pho 250 ul
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NB100-2744 Schizosaccharomyces pombe CDK unit 0.1 mg
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25-602 CDC5L shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2_M transition. CDC5L has been demonstrated to act as a positive 0.05 mg
31-029 CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, 0.1 mg
28-702 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.05 mg
28-673 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science Laboratory in RIKEN. 0.1 mg
29-197 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science Laboratory in RIKEN. 0.1 mg
28-655 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.1 mg
28-654 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.05 mg
27-302 RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protei 0.1 mg
20-272-191627 ATF1 - S.pombe - Mouse monoclonal [ATF1 2A9 _ 8] to ATF1 - S.pombe; Activating transcription factor 1; TREB36 protein Monoclonal 0.1 mg
20-372-60179 CDC5 cell division cycle 5-like (S. pombe) (CDC5L) - Mouse monoclonal anti-human CDC5L antibody; Cdc5-like protein; Pombe cdc5-related protein Monoclonal 0.1 mg
AB1I144 Polyclonal Antibodies: Anti-CrPV Genome polyprotein Polyclonal Antibody; Specificity: Anti-CrPV Genome polyprotein Polyclonal Antibody ; Application: IHC 0.1mg
LF-MA40980 anti-Rad1 (s. Pombe) Homolog (rad1), Mouse monoclonal to Rad1 (s. Pombe) Homolog (rad1), Isotype IgG, Host Mouse 50 ug
HGA001-100 HelixAmp™ Genome Amplifier 100 Rxns
HGA001-500 HelixAmp™ Genome Amplifier 500 Rxns
HGA001-25 HelixAmp™ Genome Amplifier 25 Rxns


 

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