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Pubmed ID :12135769
Publication Date : //

Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12.


We cloned in silico a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T), pp-GalNAc-T12. The deduced amino acid sequence of pp-GalNAc-T12 contains all conserved motifs in pp-GalNAc-T family proteins. Quantitative real time polymerase chain reaction analysis revealed that the pp-GalNAc-T12 transcript was expressed mainly in digestive organs such as stomach, small intestine and colon. The recombinant pp-GalNAc-T12 transferred GalNAc to the mucin-derived peptides such as the Muc1a, Muc5AC, EA2 peptides and the GalNAc-Muc5AC glycopeptide. Since mucins are glycoproteins mainly produced in the digestive organs, our results suggest that pp-GalNAc-T12 plays an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.

Authors : Guo Jian-Ming , Zhang Yan , Cheng Lamei , Iwasaki Hiroko , Wang Han , Kubota Tomomi , Tachibana Kouichi , Narimatsu Hisashi ,

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GALNT7 GALNT5 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
GALNT6 GALNT4 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
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GALNT2 GALNT13 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
GALNT4 GALNT2 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
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GALNTL2 GALNT9 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
GALNT9 GALNT7 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
GALNT8 GALNT6 Gene UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
CSB-EL009204RA Rat UDP-N-acetyl-alpha-D-galactosamine polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) (GALNT10) ELISA kit, Species Rat, Sample Type serum, plasma 96T
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