Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :12218036
Publication Date : //

Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.


Virulence and immunity are poorly understood in Mycobacterium tuberculosis. We sequenced the complete genome of the M. tuberculosis clinical strain CDC1551 and performed a whole-genome comparison with the laboratory strain H37Rv in order to identify polymorphic sequences with potential relevance to disease pathogenesis, immunity, and evolution. We found large-sequence and single-nucleotide polymorphisms in numerous genes. Polymorphic loci included a phospholipase C, a membrane lipoprotein, members of an adenylate cyclase gene family, and members of the PE/PPE gene family, some of which have been implicated in virulence or the host immune response. Several gene families, including the PE/PPE gene family, also had significantly higher synonymous and nonsynonymous substitution frequencies compared to the genome as a whole. We tested a large sample of M. tuberculosis clinical isolates for a subset of the large-sequence and single-nucleotide polymorphisms and found widespread genetic variability at many of these loci. We performed phylogenetic and epidemiological analysis to investigate the evolutionary relationships among isolates and the origins of specific polymorphic loci. A number of these polymorphisms appear to have occurred multiple times as independent events, suggesting that these changes may be under selective pressure. Together, these results demonstrate that polymorphisms among M. tuberculosis strains are more extensive than initially anticipated, and genetic variation may have an important role in disease pathogenesis and immunity.

Authors : Fleischmann R D , Alland D , Eisen J A , Carpenter L , White O , Peterson J , DeBoy R , Dodson R , Gwinn M , Haft D , Hickey E , Kolonay J F , Nelson W C , Umayam L A , Ermolaeva M , Salzberg S L , Delcher A , Utterback T , Weidman J , Khouri H , Gill J , Mikula A , Bishai W , Jacobs W R , Venter J C , Fraser C M ,

Related products :

Catalog number Product name Quantity
28-654 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.05 mg
28-655 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.1 mg
28-673 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science Laboratory in RIKEN. 0.1 mg
28-702 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science laboratory in RIKEN. 0.05 mg
29-197 cDNA library was prepared and sequenced in Mouse Genome Encyclopedia Project of Genome Exploration Research Group in Riken Genomic Sciences Center and Genome Science Laboratory in RIKEN. 0.1 mg
FR068 differentiate between Mycobacterium tuberculosis genotype beijing and non beijing strains 100
FR068 differentiate between Mycobacterium tuberculosis genotype beijing and non beijing strains FLUORGENIC REALTIME PCR - READY TO USE KIT 100 REACTIONS
FR 068 differentiate between Mycobacterium tuberculosis genotype beijing and non beijing strains 100 reactions
FR068 differentiate between Mycobacterium tuberculosis genotype beijing and non beijing strains ,FLUORGENIC REALTIME PCR - READY TO USE KITS, REAL TIME PCR 100 REACTIONS
SCH-OBT1832 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 16kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.1 mg
SCH-OBT1833 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 16kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.1 mg
OBT1833 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 16kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.1 mg
OBT1832 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 16kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.1 mg
0100-0518 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
SCH-0100-0520 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
0100-0519 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
SCH-0100-0518 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
SCH-0100-0519 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
0100-0520 MOUSE ANTI MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Monoclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Mouse, Format Purified, Isotypes IgG 0.2 mg
OBT0947 RABBIT ANTI MYCOBACTERIUM TUBERCULOSIS, Product Type Polyclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, 1 ml
0100-0158 RECOMBINANT MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Recombinant Protein, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host N_A, Format Rec. Protein, Isotypes 50 µg
SCH-0100-0158 RECOMBINANT MYCOBACTERIUM TUBERCULOSIS 38kDa ANTIGEN, Product Type Recombinant Protein, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host N_A, Format Rec. Protein, Isotypes 50 µg
SCH-OBT0947 RABBIT ANTI MYCOBACTERIUM TUBERCULOSIS, Product Type Polyclonal Antibody, Specificity MYCOBACTERIUM TUBERCULOSIS, Target Species Bacterial, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, 1 ml
11-491-C025 Rabbit Polyclonal to Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) Antigen Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) Isotype Antigen Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) 0.025 mg
11-491-C100 Rabbit Polyclonal to Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) Antigen Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) Isotype Antigen Mycobacterium tuberculosis antigen EsaT_6 (Rv3875) 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur