Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :12591244
Publication Date : //

The drosophila angiotensin-converting enzyme homologue Ance is required for spermiogenesis.


The Angiotensin-converting enzyme (Ance) gene of Drosophila melanogaster is a homologue of mammalian angiotensin-converting enzyme (ACE), a peptidyl dipeptidase implicated in regulation of blood pressure and male fertility. In Drosophila, Ance protein is present in vesicular structures within spermatocytes and immature spermatids. It is also present within the lumen of the testis and the waste bag, and is associated with the surface of elongated spermatid bundles. Ance mRNA is found mainly in large primary spermatocytes and is not detectable in cyst cells. Testes lacking germ cells have reduced levels of ACE activity, and no Ance protein is detectable by immunocytochemistry, indicating that the germ cells are the major site of Ance synthesis. Ance mutant testes lack individualised sperm and have very few actin-based individualisation complexes. Spermatid nuclei undergo scattering along the cyst and have abnormal morphology, similar to other individualisation mutants. Mutant spermatids also have abnormal ultrastructure with grossly defective mitochondrial derivatives. The failure of Ance mutant testes to form individualisation complexes may be due to a failure in correct spermatid differentiation. Taken together, the expression pattern and mutant phenotype suggest that Ance is required for spermatid differentiation, probably through the processing of a regulatory peptide synthesised within the developing cyst.

Authors : Hurst Debra , Rylett Caroline M , Isaac R Elwyn , Shirras Alan D ,

Related products :

Catalog number Product name Quantity
E1886h ELISA ACE2,ACEH,ACE-related carboxypeptidase,Angiotensin-converting enzyme 2,Angiotensin-converting enzyme homolog,Homo sapiens,Human,Metalloprotease MPROT15,UNQ868_PRO1885 96T
U1886h CLIA ACE2,ACEH,ACE-related carboxypeptidase,Angiotensin-converting enzyme 2,Angiotensin-converting enzyme homolog,Homo sapiens,Human,Metalloprotease MPROT15,UNQ868_PRO1885 96T
E1886h ELISA kit ACE2,ACEH,ACE-related carboxypeptidase,Angiotensin-converting enzyme 2,Angiotensin-converting enzyme homolog,Homo sapiens,Human,Metalloprotease MPROT15,UNQ868_PRO1885 96T
U1886h CLIA kit ACE2,ACEH,ACE-related carboxypeptidase,Angiotensin-converting enzyme 2,Angiotensin-converting enzyme homolog,Homo sapiens,Human,Metalloprotease MPROT15,UNQ868_PRO1885 96T
18-661-15170 Angiotensin-converting enzyme 2 - EC 3.4.17.-; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH Polyclonal 0.1 mg
18-661-15169 Angiotensin-converting enzyme 2 - EC 3.4.17.-; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH Polyclonal 0.1 mg
18-661-15167 Angiotensin-converting enzyme 2 - EC 3.4.17.-; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH Polyclonal 0.1 mg
18-661-15168 Angiotensin-converting enzyme 2 - EC 3.4.17.-; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH Polyclonal 0.1 mg
20-272-190613 Angiotensin Converting Enzyme - Mouse monoclonal [ 9B9] to Angiotensin Converting Enzyme; EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.5 ml
20-272-190609 Angiotensin Converting Enzyme - Mouse monoclonal [2E2] to Angiotensin Converting Enzyme; EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.5 ml
20-272-190612 Angiotensin Converting Enzyme - Mouse monoclonal [3C5] to Angiotensin Converting Enzyme; EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.5 ml
20-272-190610 Angiotensin Converting Enzyme ( Biotin ) - Mouse monoclonal [i2H5] to Angiotensin Converting Enzyme ( Biotin ); EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.05 mg
20-272-190611 Angiotensin Converting Enzyme ( FITC ) - Mouse monoclonal [i2H5] to Angiotensin Converting Enzyme ( FITC ); EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.05 mg
20-272-190598 Angiotensin Converting Enzyme ( FITC ) - Mouse monoclonal [ i1A8] to Angiotensin Converting Enzyme ( FITC ); EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.05 mg
20-272-190614 Angiotensin Converting Enzyme ( Biotin ) - Mouse monoclonal [9B9] to Angiotensin Converting Enzyme ( Biotin ); EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.05 mg
20-272-190615 Angiotensin Converting Enzyme ( FITC ) - Mouse monoclonal [9B9] to Angiotensin Converting Enzyme ( FITC ); EC 3.4.15.1; Dipeptidyl carboxypeptidase I; Kininase II; CD143 antigen Monoclonal 0.05 mg
20-272-192338 Angiotensin Converting Enzyme - Mouse monoclonal [M4110421] to Angiotensin Converting Enzyme Monoclonal 0.05 mg
orb70441 Angiotensin 1-Converting Enzyme Substrate peptide This is Angiotensin 1-Converting Enzyme Substrate peptide. For research use only. 1 mg
orb70435 Angiotensin Converting Enzyme Inhibitor peptide This is Angiotensin Converting Enzyme Inhibitor peptide. For research use only. 1 mg
orb60743 Enalapril maleate Enalapril maleate(Vasotec ), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin 100 mg
C419 Angiotensin-Converting Enzyme 2 ACE-2 lmg
Y102941 Angiotensin Converting Enzyme (ACE) 100 ug
Y102116 Angiotensin Converting Enzyme (ACE) 100ug
Y102016 Angiotensin Converting Enzyme (ACE) 100 ug
E02A0709 Rat Angiotensin II Converting Enzyme 96 Tests/kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur