Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :12643545
Publication Date : //

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.


Melanin is a heterogeneous biopolymer produced only by specific cells termed melanocytes, which synthesize and deposit the pigment in specialized membrane-bound organelles known as melanosomes. Although melanosomes have been suspected of being closely related to lysosomes and platelets, the total number of melanosomal proteins is still unknown. Thus far, six melanosome-specific proteins have been identified, and the challenge is to characterize the complete proteome of the melanosome to further understand its mechanism of biogenesis. In this report, we used mass spectrometry and subcellular fractionation to identify protein components of early melanosomes. Using this approach, we have identified all 6 of the known melanosome-specific proteins, 56 proteins that are shared with other organelles, and confirmed the presence of 6 novel melanosomal proteins using western blotting and by immunohistochemistry.

Authors : Basrur Venkatesha , Yang Feng , Kushimoto Tsuneto , Higashimoto Youichiro , Yasumoto Ken-ichi , Valencia Julio , Muller Jacqueline , Vieira Wilfred D , Watabe Hidenori , Shabanowitz Jeffrey , Hearing Vincent J , Hunt Donald F , Appella Ettore ,

Related products :

Catalog number Product name Quantity
XGC-BiRDS-ChipSeq12 Bioinformatics analysis of ChipSeq data for identification of binding sites for DNA-associated proteins Upto 12 samples
40130005-1 Proteomic Grade Detergent Pack 8 PK(s)
IQ77 Mouse Anti-Human CD34 Target Antigen CD34 Host Isotype Mouse IgG1 Application Identification of haemopoietic progenitor cells; Studies into the control mechanisms of early haemopoiesis; Purificati 0.1ml (1mg/ml)
SP2185b Melanosomal Antigen II 5mg
SP2185a Melanosomal Antigen II
SP2185a Melanosomal Antigen II 1 mg
SP2185b Melanosomal Antigen II 5 mg
SP2185a Melanosomal Antigen II 1mg
SP2185b Melanosomal Antigen II
32-171 Hermansky-Pudlak syndrome 1.This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a compo 0.1 mL
TotalLabQuant Base package*: 1D image analysis plus colony counting and array analysis
AS-MRA-P8 MARIA™ ANALYSIS SERVICE 8-plex analysis Environmental Testing Services 1 sample
AS-MRA-P5 MARIA™ ANALYSIS SERVICE 5-plex analysis Environmental Testing Services 1 sample
XGC-BiRDS-MeDIP-Seq Bioinformatics analysis of Methylome data for Methylation analysis Sample
TotalLab Quant Base package* 1D image analysis plus colony counting and array analysis
XGC-BiRDS-WGBS Bioinformatics analysis of Whole Genome Bisulphite Sequencing data for Methylation analysis Sample
TotalLab Quant Base package* 1D image analysis plus colony counting and array analysis 1
S-0040.2 Multiplexed Analysis of Proteins using Multi Analyte Profiling Technology (xMAP) 5x
Phoretix 1D  Base package* 1D image analysis with band pattern matching, plus colony counting and array analysis
Phoretix 1D Base package* 1D image analysis with band pattern matching, plus colony counting and array analysis 1
Phoretix1D Base package*: 1D image analysis with band pattern matching, plus colony counting and array analysis
M0794 MarkerGeneTM Hydrophobic Protein Analysis Kit, Allows fast and easy measurement of proteins in complex mixtures, 1 kit
B1088 Kligler Iron Agar,Modified USE For identification of Yersinia enterocolitica.Also used for differential identification of gram_negative enteric bacilli on the basis of fermentation of dextrose, lact Qty per Litre of Medium: 57,3
B1088 Kligler Iron Agar,Modified USE For identification of Yersinia enterocolitica.Also used for differential identification of gram_negative enteric bacilli on the basis of fermentation of dextrose, lact Qty per Litre of Medium: 57,3
AS-MRA-P8 8-plex analysis MARIA™ ANALYSIS SERVICE 1 sample


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur