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Pubmed ID :15057822
Publication Date : //

Genome sequence of the Brown Norway rat yields insights into mammalian evolution.


The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

Authors : Gibbs Richard A , Weinstock George M , Metzker Michael L , Muzny Donna M , Sodergren Erica J , Scherer Steven , Scott Graham , Steffen David , Worley Kim C , Burch Paula E , Okwuonu Geoffrey , Hines Sandra , Lewis Lora , DeRamo Christine , Delgado Oliver , Dugan-Rocha Shannon , Miner George , Morgan Margaret , Hawes Alicia , Gill Rachel , Celera , Holt Robert A , Adams Mark D , Amanatides Peter G , Baden-Tillson Holly , Barnstead Mary , Chin Soo , Evans Cheryl A , Ferriera Steve , Fosler Carl , Glodek Anna , Gu Zhiping , Jennings Don , Kraft Cheryl L , Nguyen Trixie , Pfannkoch Cynthia M , Sitter Cynthia , Sutton Granger G , Venter J Craig , Woodage Trevor , Smith Douglas , Lee Hong-Mei , Gustafson Erik , Cahill Patrick , Kana Arnold , Doucette-Stamm Lynn , Weinstock Keith , Fechtel Kim , Weiss Robert B , Dunn Diane M , Green Eric D , Blakesley Robert W , Bouffard Gerard G , De Jong Pieter J , Osoegawa Kazutoyo , Zhu Baoli , Marra Marco , Schein Jacqueline , Bosdet Ian , Fjell Chris , Jones Steven , Krzywinski Martin , Mathewson Carrie , Siddiqui Asim , Wye Natasja , McPherson John , Zhao Shaying , Fraser Claire M , Shetty Jyoti , Shatsman Sofiya , Geer Keita , Chen Yixin , Abramzon Sofyia , Nierman William C , Havlak Paul H , Chen Rui , Durbin K James , Egan Amy , Ren Yanru , Song Xing-Zhi , Li Bingshan , Liu Yue , Qin Xiang , Cawley Simon , Worley Kim C , Cooney A J , D'Souza Lisa M , Martin Kirt , Wu Jia Qian , Gonzalez-Garay Manuel L , Jackson Andrew R , Kalafus Kenneth J , McLeod Michael P , Milosavljevic Aleksandar , Virk Davinder , Volkov Andrei , Wheeler David A , Zhang Zhengdong , Bailey Jeffrey A , Eichler Evan E , Tuzun Eray , Birney Ewan , Mongin Emmanuel , Ureta-Vidal Abel , Woodwark Cara , Zdobnov Evgeny , Bork Peer , Suyama Mikita , Torrents David , Alexandersson Marina , Trask Barbara J , Young Janet M , Huang Hui , Wang Huajun , Xing Heming , Daniels Sue , Gietzen Darryl , Schmidt Jeanette , Stevens Kristian , Vitt Ursula , Wingrove Jim , Camara Francisco , Mar Albà M , Abril Josep F , Guigo Roderic , Smit Arian , Dubchak Inna , Rubin Edward M , Couronne Olivier , Poliakov Alexander , Hübner Norbert , Ganten Detlev , Goesele Claudia , Hummel Oliver , Kreitler Thomas , Lee Young-Ae , Monti Jan , Schulz Herbert , Zimdahl Heike , Himmelbauer Heinz , Lehrach Hans , Jacob Howard J , Bromberg Susan , Gullings-Handley Jo , Jensen-Seaman Michael I , Kwitek Anne E , Lazar Jozef , Pasko Dean , Tonellato Peter J , Twigger Simon , Ponting Chris P , Duarte Jose M , Rice Stephen , Goodstadt Leo , Beatson Scott A , Emes Richard D , Winter Eitan E , Webber Caleb , Brandt Petra , Nyakatura Gerald , Adetobi Margaret , Chiaromonte Francesca , Elnitski Laura , Eswara Pallavi , Hardison Ross C , Hou Minmei , Kolbe Diana , Makova Kateryna , Miller Webb , Nekrutenko Anton , Riemer Cathy , Schwartz Scott , Taylor James , Yang Shan , Zhang Yi , Lindpaintner Klaus , Andrews T Dan , Caccamo Mario , Clamp Michele , Clarke Laura , Curwen Valerie , Durbin Richard , Eyras Eduardo , Searle Stephen M , Cooper Gregory M , Batzoglou Serafim , Brudno Michael , Sidow Arend , Stone Eric A , Venter J Craig , Payseur Bret A , Bourque Guillaume , López-Otín Carlos , Puente Xose S , Chakrabarti Kushal , Chatterji Sourav , Dewey Colin , Pachter Lior , Bray Nicolas , Yap Von Bing , Caspi Anat , Tesler Glenn , Pevzner Pavel A , Haussler David , Roskin Krishna M , Baertsch Robert , Clawson Hiram , Furey Terrence S , Hinrichs Angie S , Karolchik Donna , Kent William J , Rosenbloom Kate R , Trumbower Heather , Weirauch Matt , Cooper David N , Stenson Peter D , Ma Bin , Brent Michael , Arumugam Manimozhiyan , Shteynberg David , Copley Richard R , Taylor Martin S , Riethman Harold , Mudunuri Uma , Peterson Jane , Guyer Mark , Felsenfeld Adam , Old Susan , Mockrin Stephen , Collins Francis , ,

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