Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15489286
Publication Date : //

Genome-wide mRNA surveillance is coupled to mRNA export.


Nuclear export of mRNA is a central step in gene expression that shows extensive coupling to transcription and transcript processing. However, little is known about the fate of mRNA and its export under conditions that damage the DNA template and RNA itself. Here we report the discovery of four new factors required for mRNA export through a screen of all annotated nonessential Saccharomyces cerevisiae genes. Two of these factors, mRNA surveillance factor Rrp6 and DNA repair protein Lrp1, are nuclear exosome components that physically interact with one another. We find that Lrp1 mediates specific mRNA degradation upon DNA-damaging UV irradiation as well as general mRNA degradation. Lrp1 requires Rrp6 for genomic localization to genes encoding its mRNA targets, and Rrp6 genomic localization in turn correlates with transcription. Further, Rrp6 and Lrp1 are both required for repair of UV-induced DNA damage. These results demonstrate coupling of mRNA surveillance to mRNA export and suggest specificity of the RNA surveillance machinery for different transcript populations. Broadly, these findings link DNA and RNA surveillance to mRNA export.

Authors : Hieronymus Haley , Yu Michael C , Silver Pamela A ,

Related products :

Catalog number Product name Quantity
25-352 UPF1 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading 0.05 mg
25-666 UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to th 0.05 mg
29-462 UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to th 0.1 mg
18-003-43567 mRNA export factor - mRNA-associated protein mrnp 41; Rae1 protein homolog Polyclonal 0.05 mg Aff Pur
18-003-43568 mRNA export factor - mRNA-associated protein mrnp 41; Rae1 protein homolog Polyclonal 0.05 mg Aff Pur
EIAAB33693 Homo sapiens,Human,mRNA export factor,mRNA-associated protein mrnp 41,MRNP41,RAE1,Rae1 protein homolog
EIAAB33692 Bos taurus,Bovine,mRNA export factor,mRNA-associated protein mrnp 41,MRNP41,RAE1,Rae1 protein homolog
EIAAB33691 Mouse,mRNA export factor,mRNA-associated protein mrnp 41,Mrnp41,Mus musculus,Rae1,Rae1 protein homolog
EIAAB33690 mRNA export factor,mRNA-associated protein mrnp 41,Mrnp41,Rae1,Rae1 protein homolog,Rat,Rattus norvegicus
EIAAB33696 mRNA export factor,mRNA-associated protein mrnp 41,MRNP41,Pig,RAE1,Rae1 protein homolog,Sus scrofa
29-373 Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. SYNCRIP may be involved in translationally coupled mRNA turnover. It implicated with other RNA-binding proteins 0.1 mg
29-374 Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. SYNCRIP may be involved in translationally coupled mRNA turnover. It implicated with other RNA-binding proteins 0.1 mg
26-565 DCP1B may play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. It may remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5' 0.05 mg
29-510 DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-pho 0.05 mg
EIAAB28324 Homo sapiens,Human,mRNA export factor TAP,Nuclear RNA export factor 1,NXF1,TAP,Tip-associated protein,Tip-associating protein
EIAAB28326 mRNA export factor TAP,Nuclear RNA export factor 1,Nxf1,Rat,Rattus norvegicus,Tap,Tip-associated protein,Tip-associating protein
EIAAB28325 Mouse,mRNA export factor TAP,Mus musculus,Nuclear RNA export factor 1,Nxf1,Tap,Tip-associated protein,Tip-associating protein
CK5P1_RAT Human ELISA Kit FOR mRNA export factor 96T
SH24B_MOUSE Human ELISA Kit FOR mRNA export factor 96T
CSB-EL019276RA Rat mRNA export factor(RAE1) ELISA kit 96T
E0100h Human ELISA Kit FOR mRNA export factor 96T
CSB-EL019276RA Rat mRNA export factor(RAE1) ELISA kit SpeciesRat 96T
CSB-EL019276BO Bovine mRNA export factor(RAE1) ELISA kit 96T
CSB-EL019276MO Mouse mRNA export factor(RAE1) ELISA kit 96T
CSB-EL019276PI Pig mRNA export factor(RAE1) ELISA kit SpeciesPig 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur