Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15759005
Publication Date : //

The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.


Representing the 60 trillion cells that build a human body, a sperm and an egg meet, recognize each other, and fuse to form a new generation of life. The factors involved in this important membrane fusion event, fertilization, have been sought for a long time. Recently, CD9 on the egg membrane was found to be essential for fusion, but sperm-related fusion factors remain unknown. Here, by using a fusion-inhibiting monoclonal antibody and gene cloning, we identify a mouse sperm fusion-related antigen and show that the antigen is a novel immunoglobulin superfamily protein. We have termed the gene Izumo and produced a gene-disrupted mouse line. Izumo-/- mice were healthy but males were sterile. They produced normal-looking sperm that bound to and penetrated the zona pellucida but were incapable of fusing with eggs. Human sperm also contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs.

Authors : Inoue Naokazu , Ikawa Masahito , Isotani Ayako , Okabe Masaru ,

Related products :

Catalog number Product name Quantity
26-603 The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion.The sperm-specific protein Izumo, named for a Japanes 0.05 mg
EH1813 Izumo sperm-egg fusion protein 1 Elisa Kit 96T
CSB-EL011926RA Rat Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit 96T
CSB-EL003453HU Human Izumo sperm-egg fusion protein 4(C19orf36) ELISA kit 96T
CD94 Recombinant Human Izumo Sperm-Egg Fusion Protein 4 per IZUMO4 (C-Fc) 10ug
CSB-EL011926MO Mouse Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit 96T
abx109313 Polyclonal Rabbit Izumo sperm-egg fusion protein 4 Antibody 100 μg
abx108440 Polyclonal Rabbit Izumo sperm-egg fusion protein 4 Antibody (HRP) 100 μg
CSB-EL003457HU Human Izumo sperm-egg fusion protein 2(C19orf41) ELISA kit 96T
CSB-EL011926HU Human Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit 96T
CSB-EL011926RA Rat Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit SpeciesRat 96T
abx107019 Polyclonal Rabbit Izumo sperm-egg fusion protein 4 Antibody (FITC) 100 μg
CSB-EL011926MO Mouse Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit SpeciesMouse 96T
abx105601 Polyclonal Rabbit Izumo sperm-egg fusion protein 4 Antibody (Biotin) 100 μg
CSB-EL003453HU Human Izumo sperm-egg fusion protein 4(C19orf36) ELISA kit SpeciesHuman 96T
CSB-EL011926HU Human Izumo sperm-egg fusion protein 1(IZUMO1) ELISA kit SpeciesHuman 96T
CSB-EL003457HU Human Izumo sperm-egg fusion protein 2(C19orf41) ELISA kit SpeciesHuman 96T
IZUM3_MOUSE ELISA Kit FOR Izumo sperm-egg fusion protein 3; organism: Mouse; gene name: Izumo3 96T
IZUM2_MOUSE ELISA Kit FOR Izumo sperm-egg fusion protein 2; organism: Mouse; gene name: Izumo2 96T
E1556m ELISA Kit FOR Izumo sperm-egg fusion protein 1; organism: Mouse; gene name: Izumo1 96T
30-951 TEX14 belongs to the protein kinase superfamily. It contains 3 ANK repeats and 1 protein kinase domain. TEX14 is required for spermatogenesis and male fertility. It may be required for normal structur 0.05 mg
E7357h Human Izumo Sperm Egg Fusion 4 ELISA Kit 96T
JAG2 IZUMO1 Gene izumo sperm-egg fusion 1
E3966h Human Izumo Sperm Egg Fusion 1 ELISA Kit 96T
E7836h Human Izumo Sperm Egg Fusion 3 ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur