Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :15908231
Publication Date : //

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.


The matrix protein VP40 is an indispensable component of viral assembly and budding by the Ebola virus. VP40 is a monomer in solution, but can fold into hexameric and octameric states, two oligomeric conformations that play central roles in the Ebola viral life cycle. While the X-ray structures of monomeric and octameric VP40 have been determined, the structure of hexameric VP40 has only been solved by three-dimensional electron microscopy (EM) to a resolution of approximately 30 A. In this paper, we present the refinement of the EM reconstruction of truncated hexameric VP40 to approximately 20 A and the construction of an all-atom model (residues 44-212) using the EM model at approximately 20 A and the X-ray structure of monomeric VP40 as templates. The hexamer model suggests that the monomer-hexamer transition involves a conformational change in the N-terminal domain that is not evident during octamerization and therefore, may provide the basis for elucidating the biological function of VP40.

Authors : Nguyen Tam Luong , Schoehn Guy , Weissenhorn Winfried , Hermone Ann R , Burnett James C , Panchal Rekha G , McGrath Connor , Zaharevitz Dan W , Aman M Javad , Gussio Rick , Bavari Sina ,

Related products :

Catalog number Product name Quantity
KMA0021 The Model of Bone Structure Set
KMA1082 The model of the spinal internal structure Set
KMR02 Relief model of skin structure Set
KMA0021 The Model of Bone Structure, 400x420x300
KMH001 Model of structure of digestive canal, 3 parts Set
KMH007 Microscopic structure model of spleen, 1 part Set
KMA1082 The model of the spinal internal structure, Natural size
KMR02 Relief model of skin structure, Natural size
KMH017 Model of structure placenta umbilical cord, 2 parts Set
KMH007 Microscopic structure model of spleen, 1 part, 330x250x180
KMCT3 Buttocks Intramuscular Injection & Anatomic Structure Model
KMH040 Ultra structure model of a skeletal muscle fiber, 1 part Set
KMH050 Model showing ephapse and structure of neuro fiber, 4 parts Set
KMH017 Model of structure placenta umbilical cord, 2 parts, 205x205x110
KMA139 Model of inside structure and pathways in the brain stem, 3 parts Set
KMH050 Model showing ephapse and structure of neuro fiber, 4 parts, 310x160x280 5x
KMA139 Model of inside structure and pathways in the brain stem, 3 parts, 220x210x101
KMH037 Model showing molecular structure and construction of the muscle on bone, 1 part Set
KMH040 Ultra structure model of a skeletal muscle fiber, 1 part, 205x195x285
42615-29-2 Linear Alkyl benzene sulfonic acid sodim LAS; Model structure 1g
25-359 Twinkle is a mitochondrial protein with structural similarity to the phage T7 primase_helicase (GP4) and other hexameric ring helicases. The twinkle protein colocalizes with mtDNA in mitochondrial nuc 0.05 mg
25-360 Twinkle is a mitochondrial protein with structural similarity to the phage T7 primase_helicase (GP4) and other hexameric ring helicases. The twinkle protein colocalizes with mtDNA in mitochondrial nuc 0.05 mg
30-709 The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segm 0.1 mg
30-710 The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segm 0.05 mg
KMH037 Model showing molecular structure and construction of the muscle on bone, 1 part, 250x250x540


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur