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Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution.
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WP137: Fatty Acid Biosynthesis, Initial Steps
WP2107: pathways in human cancer
WP582: Cre-lox for W846X
Related Genes :
 Accelerating the Smith-Waterman algorithm with interpair pruning and band optimization for the all-pairs comparison of base sequences.
 Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage.
 Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder.
 Initial sequence of the chimpanzee genome and comparison with the human genome.
 Insights from human/mouse genome comparisons.
 Selectively primed adaptive driver RDA (SPAD-RDA): an improved method for subtractive hybridization.
 Three independent insertions of retrovirus-like sequences in the haptoglobin gene cluster of primates.
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