Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of alleles even within species that have dispersed and expanded in size recently. Phylogenetic analysis of 277 human mitochondrial genomes revealed a significant (P < 0.01) excess of rRNA and nonsynonymous base substitutions among hotspots of recurrent mutation. Most hotspots involved transitions from guanine to adenine that, with thymine-to-cytosine transitions, illustrate the asymmetric bias in codon usage at synonymous sites on the heavy-strand DNA. The mitochondrion-encoded tRNAThr varied significantly more than any other tRNA gene. Threonine and valine codons were involved in 259 of the 414 amino acid replacements observed. The ratio of nonsynonymous changes from and to threonine and valine differed significantly (P = 0.003) between populations with neutral (22/58) and populations with significantly negative Tajima's D values (70/76), independent of their geographic location. In contrast to a recent suggestion that the excess of nonsilent mutations is characteristic of Arctic populations, implying their role in cold adaptation, we demonstrate that the surplus of nonsynonymous mutations is a general feature of the young branches of the phylogenetic tree, affecting also those that are found only in Africa. We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups.
Authors : Kivisild Toomas , Shen Peidong , Wall Dennis P , Do Bao , Sung Raphael , Davis Karen , Passarino Giuseppe , Underhill Peter A , Scharfe Curt , Torroni Antonio , Scozzari Rosaria , Modiano David , Coppa Alfredo , de Knijff Peter , Feldman Marcus , Cavalli-Sforza Luca L , Oefner Peter J ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
email@example.com | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1263: Mitochondrial Gene Expression
WP1301: Mitochondrial Gene Expression
WP1368: Mitochondrial Gene Expression
WP1502: Mitochondrial biogenesis
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP2107: pathways in human cancer
WP296: TCA Cycle - biocyc
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP391: Mitochondrial Gene Expression
WP401: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP406: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP419: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP448: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP498: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP525: Mitochondrial Unfolded-Protein Response
WP62: Mitochondrial tRNA Synthetases
WP763: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP871: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP928: Mitochondrial Gene Expression
WP989: Mitochondrial LC-Fatty Acid Beta-Oxidation
Related Genes :
 Codon based co-occurrence network motifs in human mitochondria.
 The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes.
 MtDNA genomes reveal a relaxation of selective constraints in low-BMI individuals in a Uyghur population.
 Genome sequence, population history, and pelage genetics of the endangered African wild dog (Lycaon pictus).
 Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians.
 Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance.
 Mitochondrial genomes are retained by selective constraints on protein targeting.
 Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing.
 A genetic view of the mitochondrial role in ageing: killing us softly.
 Full mtGenome reference data: development and characterization of 588 forensic-quality haplotypes representing three U.S. populations.
Enter catalog number :