Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :16200078
Publication Date : //

Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.


The Sloan Kettering Virus (Ski) family of nuclear oncoproteins represses transforming growth factor-beta (TGF-beta) signaling through inhibition of transcriptional activity of Smad proteins. Here, we report the discovery of a new functional Smad suppressing element on chromosome 18 (Fussel-18). Fussel-18 encodes for a protein of 297 amino acids sharing characteristic structural features, significant homology and similar genomic organization with the homolog Ski family members, Ski and Ski-related novel sequence (Sno). In contrast to Ski and Sno, which are ubiquitously expressed in human tissues, in situ hybridization, RT-PCR, Western blot and immunohistochemistry revealed a highly specific expression pattern for Fussel-18 in neuronal tissues, especially in the cerebellum, the spinal cord and dorsal root ganglia, during both embryogenesis and adult stage. Functionally, we determined interaction of Fussel-18 with Smad 2 and Smad 3 together with an inhibitory activity on TGF-beta signaling. Fussel-18 is the first example of a Smad-binding protein with a highly restricted expression pattern within the nervous system.

Authors : Arndt Stephanie , Poser Ina , Schubert Thomas , Moser Markus , Bosserhoff Anja-Katrin ,

Related products :

Catalog number Product name Quantity
29-758 PLUNC is the human homolog of murine plunc and is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this protein is not known, however, it has be 0.05 mg
EIAAB38579 CORL1,Functional Smad-suppressing element on chromosome 15,FUSSEL15,Fussel-15,Homo sapiens,Human,Ladybird homeobox corepressor 1,LBX1 corepressor 1,LBXCOR1,SKI family transcriptional corepressor 1,SKO
EIAAB38581 CORL2,Functional Smad-suppressing element on chromosome 18,FUSSEL18,Fussel-18,Homo sapiens,Human,Ladybird homeobox corepressor 1-like protein,LBX1 corepressor 1-like protein,SKI family transcriptional
EIAAB42028 Mouse,Mus musculus,Testis-expressed sequence 9 protein,Testis-specifically expressed protein 1,Tex9,Tsec-1
28-669 Spz1, a novel bHLH-Zip protein, is specifically expressed in testis. 0.1 mg
13HTX003-00100 Hainantoxin III peptide, specifically blocks mammalian neuronal TTX-S VGSC 100mg
13HTX003-00500 Hainantoxin III peptide, specifically blocks mammalian neuronal TTX-S VGSC 500mg
13HTX003-01000 Hainantoxin III peptide, specifically blocks mammalian neuronal TTX-S VGSC 1000mg
27-987 BHLHB2 is a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is 0.05 mg
IC-1006 pEco-T7-cHis PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells, for E Coli expression of C-term His-tagged protein. 10 x 50ul/ea
IC-1004 pEco-T7-nGST PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells for E Coli expression of N-term GST-tagged protein. 10 x 50ul/ea
IC-1001 pEco-T7-nHis PCR cloning kit: PCR cloning kit with a built-in vector (T7 promoter based) in provided cloning cells for E Coli expression of N-term His-tagged protein. 10 x 50ul/ea
28-737 MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the me 0.1 mg
28-736 MTA1 encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the me 0.1 mg
IC-1003 pEco-BAD-nHis PCR cloning kit: PCR cloning kit with a built-in vector (non-T7 promoter based) in provided cloning cells for E Coli expression of N-term His-tagged protein, specially designed for toxic 10 x 50ul/ea
28-186 RNF36 is specifically expressed in germ cells at round spermatid stages during spermatogenesis. The protein encoded by this gene contains an N-terminal RING finger motif, a B-box, and a C-terminal B-3 0.05 mg
IC-1002 pEco-suCMV-nHis-(Neo) PCR cloning kit: PCR cloning kit with a built-in mammalian expression vector (with neomycin selection marker) in provided cloning cells. The vector containing an engineered super 10 x 50ul/ea
29-962 SLC26A5 is a member of the SLC26A_SulP transporter family. SLC26A5 is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are 0.1 mg
28-982 FOXB1 is a winged helix_forkhead transcription factor. FOXB1 is specifically expressed in the developing central nervous system (CNS). Early embryonic FOXB1 expression is restricted to the mammiliary 0.1 mg
EIAAB38578 Corl1,Fussel-15 homolog,Ladybird homeobox corepressor 1,Lbx1 corepressor 1,Lbxcor1,Mouse,Mus musculus,SKI family transcriptional corepressor 1,Skor1,Transcriptional corepressor Corl1
29-759 Subcellular location of HAO1 is the peroxisome. Specifically, HAO1 is expressed primarily in liver and pancreas and is most active on glycolate, a two-carbon substrate. The protein is also active on 2 0.05 mg
RN-200 Rat Premade Northern Blot Rat Neuronal Tissues 1 Blot
RW-200 Rat Premade Western Blot Rat Neuronal Tissues 1 Blot
IC-1007 pEco-CMV-cHis-(Neo) PCR cloning kit: PCR cloning kit with a built-in mammalian expression vector (with Neomycin selection marker) in provided cloning cells, for mammalian expression of C-term His-tagg 10 x 50ul/ea
73-001 mAb TRA54 Many transcripts for proteins specifically expressed in haploid germ cells are synthesized in the spermatogenesis. A monoclonal antibody TRA54 recognizes specific organelles in germ cell cyt 50 ug


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur