Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :16407407
Publication Date : //

Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.


Mitochondria consist of four compartments-outer membrane, intermembrane space, inner membrane, and matrix--with crucial but distinct functions for numerous cellular processes. A comprehensive characterization of the proteome of an individual mitochondrial compartment has not been reported so far. We used a eukaryotic model organism, the yeast Saccharomyces cerevisiae, to determine the proteome of highly purified mitochondrial outer membranes. We obtained a coverage of approximately 85% based on the known outer membrane proteins. The proteome represents a rich source for the analysis of new functions of the outer membrane, including the yeast homologue (Hfd1/Ymr110c) of the human protein causing Sjögren-Larsson syndrome. Surprisingly, a subclass of proteins known to reside in internal mitochondrial compartments were found in the outer membrane proteome. These seemingly mislocalized proteins included most top scorers of a recent genome-wide analysis for mRNAs that were targeted to mitochondria and coded for proteins of prokaryotic origin. Together with the enrichment of the precursor form of a matrix protein in the outer membrane, we conclude that the mitochondrial outer membrane not only contains resident proteins but also accumulates a conserved subclass of preproteins destined for internal mitochondrial compartments.

Authors : Zahedi Rene P , Sickmann Albert , Boehm Andreas M , Winkler Christiane , Zufall Nicole , Schönfisch Birgit , Guiard Bernard , Pfanner Nikolaus , Meisinger Chris ,

Related products :

Catalog number Product name Quantity
EIAAB43394 Homo sapiens,Human,KIAA0016,Mitochondrial 20 kDa outer membrane protein,Mitochondrial import receptor subunit TOM20 homolog,Outer mitochondrial membrane receptor Tom20,TOMM20
201-20-5997 TOMM20{translocase of outer mitochondrial membrane 20 homolog (yeast)}rabbit.pAb 0.2ml
201-20-5998 TOMM22{translocase of outer mitochondrial membrane 22 homolog (yeast)}rabbit.pAb 0.2ml
201-20-6000 TOMM40{translocase of outer mitochondrial membrane 40 homolog (yeast)}rabbit.pAb 0.2ml
EIAAB43393 Mitochondrial 20 kDa outer membrane protein,Mitochondrial import receptor subunit TOM20 homolog,Outer mitochondrial membrane receptor Tom20,Rat,Rattus norvegicus,Tomm20
EIAAB43392 Bos taurus,Bovine,Mitochondrial 20 kDa outer membrane protein,Mitochondrial import receptor subunit TOM20 homolog,Outer mitochondrial membrane receptor Tom20,TOMM20
EIAAB43391 Mitochondrial 20 kDa outer membrane protein,Mitochondrial import receptor subunit TOM20 homolog,Mouse,Mus musculus,Outer mitochondrial membrane receptor Tom20,Tomm20
201-20-6001 TOMM6{Homo sapiens translocase of outer mitochondrial membrane 6 homolog (yeast)}rabbit.pAb 0.2ml
CSB-EL024046RA Rat translocase of outer mitochondrial membrane 20 homolog (yeast) (TOMM20) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL024054PI Pig translocase of outer mitochondrial membrane 7 homolog (yeast) (TOMM7) ELISA kit, Species Pig, Sample Type serum, plasma 96T
CSB-EL024050RA Rat translocase of outer mitochondrial membrane 40 homolog (yeast) (TOMM40) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL024051RA Rat translocase of outer mitochondrial membrane 40 homolog (yeast)-like (TOMM40L) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL024048RA Rat translocase of outer mitochondrial membrane 22 homolog (yeast) (TOMM22) ELISA kit, Species Rat, Sample Type serum, plasma 96T
EIAAB43405 Mitochondrial import receptor subunit TOM40 homolog,Mitochondrial outer membrane protein of 35 kDa,MOM35,Mom35,Mouse,Mus musculus,Protein Haymaker,Tom40,Tomm40,Translocase of outer membrane 40 kDa sub
EIAAB43402 Mitochondrial import receptor subunit TOM40 homolog,Mitochondrial outer membrane protein of 38 kDa,OM38,Rat,Rattus norvegicus,Tom40,Tom40a,Tomm40,Translocase of outer membrane 40 kDa subunit homolog
TOMM22 TOMM22 Gene translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM40L TOMM40L Gene translocase of outer mitochondrial membrane 40 homolog (yeast)-like
TOMM40 TOMM40 Gene translocase of outer mitochondrial membrane 40 homolog (yeast)
TOMM20 TOMM20 Gene translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM20L TOMM20L Gene translocase of outer mitochondrial membrane 20 homolog (yeast)-like
TOMM6 TOMM6 Gene translocase of outer mitochondrial membrane 6 homolog (yeast)
TOMM7 TOMM7 Gene translocase of outer mitochondrial membrane 7 homolog (yeast)
TOMM5 TOMM5 Gene translocase of outer mitochondrial membrane 5 homolog (yeast)
CSB-EL024052HU Human translocase of outer mitochondrial membrane 5 homolog (yeast) (TOMM5) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL024048BO Bovine translocase of outer mitochondrial membrane 22 homolog (yeast) (TOMM22) ELISA kit, Species Bovine, Sample Type serum, plasma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur