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Pubmed ID :16439620
Publication Date : //

Large-scale sequence analysis of avian influenza isolates.


The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

Authors : Obenauer John C , Denson Jackie , Mehta Perdeep K , Su Xiaoping , Mukatira Suraj , Finkelstein David B , Xu Xiequn , Wang Jinhua , Ma Jing , Fan Yiping , Rakestraw Karen M , Webster Robert G , Hoffmann Erich , Krauss Scott , Zheng Jie , Zhang Ziwei , Naeve Clayton W ,

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