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Pubmed ID :16541075
Publication Date : //

The finished DNA sequence of human chromosome 12.


Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.

Authors : Scherer Steven E , Muzny Donna M , Buhay Christian J , Chen Rui , Cree Andrew , Ding Yan , Dugan-Rocha Shannon , Gill Rachel , Gunaratne Preethi , Harris R Alan , Hawes Alicia C , Hernandez Judith , Hodgson Anne V , Hume Jennifer , Jackson Andrew , Khan Ziad Mohid , Kovar-Smith Christie , Lewis Lora R , Lozado Ryan J , Metzker Michael L , Milosavljevic Aleksandar , Miner George R , Montgomery Kate T , Morgan Margaret B , Nazareth Lynne V , Scott Graham , Sodergren Erica , Song Xing-Zhi , Steffen David , Lovering Ruth C , Wheeler David A , Worley Kim C , Yuan Yi , Zhang Zhengdong , Adams Charles Q , Ansari-Lari M Ali , Ayele Mulu , Brown Mary J , Chen Guan , Chen Zhijian , Clerc-Blankenburg Kerstin P , Davis Clay , Delgado Oliver , Dinh Huyen H , Draper Heather , Gonzalez-Garay Manuel L , Havlak Paul , Jackson Laronda R , Jacob Leni S , Kelly Susan H , Li Li , Li Zhangwan , Liu Jing , Liu Wen , Lu Jing , Maheshwari Manjula , Nguyen Bao-Viet , Okwuonu Geoffrey O , Pasternak Shiran , Perez Lesette M , Plopper Farah J H , Santibanez Jireh , Shen Hua , Tabor Paul E , Verduzco Daniel , Waldron Lenee , Wang Qiaoyan , Williams Gabrielle A , Zhang Jingkun , Zhou Jianling , Allen Carlana C , Amin Anita G , Anyalebechi Vivian , Bailey Michael , Barbaria Joseph A , Bimage Kesha E , Bryant Nathaniel P , Burch Paula E , Burkett Carrie E , Burrell Kevin L , Calderon Eliana , Cardenas Veronica , Carter Kelvin , Casias Kristal , Cavazos Iracema , Cavazos Sandra R , Ceasar Heather , Chacko Joseph , Chan Sheryl N , Chavez Dean , Christopoulos Constantine , Chu Joseph , Cockrell Raynard , Cox Caroline D , Dang Michelle , Dathorne Stephanie R , David Robert , Davis Candi Mon'Et , Davy-Carroll Latarsha , Deshazo Denise R , Donlin Jeremy E , D'Souza Lisa , Eaves Kristy A , Egan Amy , Emery-Cohen Alexandra J , Escotto Michael , Flagg Nicole , Forbes Lisa D , Gabisi Abdul M , Garza Melissa , Hamilton Cerissa , Henderson Nicholas , Hernandez Omar , Hines Sandra , Hogues Marilyn E , Huang Mei , Idlebird DeVincent G , Johnson Rudy , Jolivet Angela , Jones Sally , Kagan Ryan , King Laquisha M , Leal Belita , Lebow Heather , Lee Sandra , LeVan Jaclyn M , Lewis Lakeshia C , London Pamela , Lorensuhewa Lorna M , Loulseged Hermela , Lovett Demetria A , Lucier Alice , Lucier Raymond L , Ma Jie , Madu Renita C , Mapua Patricia , Martindale Ashley D , Martinez Evangelina , Massey Elizabeth , Mawhiney Samantha , Meador Michael G , Mendez Sylvia , Mercado Christian , Mercado Iracema C , Merritt Christina E , Miner Zachary L , Minja Emmanuel , Mitchell Teresa , Mohabbat Farida , Mohabbat Khatera , Montgomery Baize , Moore Niki , Morris Sidney , Munidasa Mala , Ngo Robin N , Nguyen Ngoc B , Nickerson Elizabeth , Nwaokelemeh Ogechi O , Nwokenkwo Stanley , Obregon Melissa , Oguh Maryann , Oragunye Njideka , Oviedo Rodolfo J , Parish Bridgette J , Parker David N , Parrish Julia , Parks Kenya L , Paul Heidie A , Payton Brett A , Perez Agapito , Perrin William , Pickens Adam , Primus Eltrick L , Pu Ling-Ling , Puazo Maria , Quiles Miyo M , Quiroz Juana B , Rabata Dina , Reeves Kacy , Ruiz San Juana , Shao Hongmei , Sisson Ida , Sonaike Titilola , Sorelle Richard P , Sutton Angelica E , Svatek Amanda F , Svetz Leah Anne , Tamerisa Kavitha S , Taylor Tineace R , Teague Brian , Thomas Nicole , Thorn Rachel D , Trejos Zulma Y , Trevino Brenda K , Ukegbu Ogechi N , Urban Jeremy B , Vasquez Lydia I , Vera Virginia A , Villasana Donna M , Wang Ling , Ward-Moore Stephanie , Warren James T , Wei Xuehong , White Flower , Williamson Angela L , Wleczyk Regina , Wooden Hailey S , Wooden Steven H , Yen Jennifer , Yoon Lillienne , Yoon Vivienne , Zorrilla Sara E , Nelson David , Kucherlapati Raju , Weinstock George , Gibbs Richard A , ,

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