Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :16545378
Publication Date : //

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.


Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release by selectively cleaving core components of the vesicular fusion machinery. The synaptic vesicle proteins Synaptotagmin-I and -II act as receptors for BoNT/B and BoNT/G. Here we show that BoNT/A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B. Binding of BoNT/A occurs at the membrane juxtaposed region preceding transmembrane domain 8. A peptide comprising the intravesicular domain between transmembrane domains 7 and 8 specifically reduces the neurotoxicity of BoNT/A at phrenic nerve preparations demonstrating the physiological relevance of this interaction.

Authors : Mahrhold Stefan , Rummel Andreas , Bigalke Hans , Davletov Bazbek , Binz Thomas ,

Related products :

Catalog number Product name Quantity
EIAAB40625 Rat,Rattus norvegicus,Sv2,Sv2a,Synaptic vesicle glycoprotein 2A,Synaptic vesicle protein 2,Synaptic vesicle protein 2A
EIAAB40624 Calcium regulator SV2A,Kiaa0736,Mouse,Mus musculus,Sv2,Sv2a,Synaptic vesicle glycoprotein 2A,Synaptic vesicle protein 2,Synaptic vesicle protein 2A
EIAAB40629 Kiaa1054,Mouse,Mus musculus,Sv2c,Synaptic vesicle glycoprotein 2C,Synaptic vesicle protein 2C
EIAAB40626 Kiaa0735,Mouse,Mus musculus,Sv2b,Synaptic vesicle glycoprotein 2B,Synaptic vesicle protein 2B
EIAAB40628 Rat,Rattus norvegicus,Sv2b,Sv2bb,Synaptic vesicle glycoprotein 2B,Synaptic vesicle protein 2B
EIAAB40631 Rat,Rattus norvegicus,Sv2c,Synaptic vesicle glycoprotein 2C,Synaptic vesicle protein 2C
25-889 The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ 0.05 mg
140A Botulinum Neurotoxin Type E Complex, Nicked, from Clostridium botulinum 10 jg.
140B Botulinum Neurotoxin Type E Complex, Nicked, from Clostridium botulinum 100 jg.
26-701 VTI1A is a V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle 0.05 mg
133B Botulinum Neurotoxin Type A Toxoid from Clostridium botulinum 50 jg.
LST138B Botulinum Neurotoxin Type B Complex from Clostridium botulinum 100 ug.
LST138A Botulinum Neurotoxin Type B Complex from Clostridium botulinum 10 ug.
LST9128B QD Botulinum Neurotoxin Type A Complex from Clostridium botulinum 100 ug.
133A Botulinum Neurotoxin Type A Toxoid from Clostridium botulinum 10 jg.
LST9128A QD Botulinum Neurotoxin Type A Complex from Clostridium botulinum 10 ug.
LST128C Botulinum Neurotoxin Type A Complex from Clostridium botulinum 100 ug.
136B Botulinum Neurotoxin Type B, nicked, from Clostridium botulinum 1,3,4 100µg
136A Botulinum Neurotoxin Type B. nicked, from Clostridium botulinum 1,3,4 10µg
LST128A Botulinum Neurotoxin Type A Complex from Clostridium botulinum 10 ug.
LST136A Botulinum Neurotoxin Type B from Clostridium botulinum 10 ug.
139 Botulinum Neurotoxin Type B Toxoid from Clostridium botulinum 10 jg.
136A Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3,4 10
LST130B Botulinum Neurotoxin Type A from Clostridium botulinum 100 ug.
LST136B Botulinum Neurotoxin Type B from Clostridium botulinum 100 ug.


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur