Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :16550171
Publication Date : //

Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome.


Arterial tortuosity syndrome (ATS) is an autosomal recessive disorder characterized by tortuosity, elongation, stenosis and aneurysm formation in the major arteries owing to disruption of elastic fibers in the medial layer of the arterial wall. Previously, we used homozygosity mapping to map a candidate locus in a 4.1-Mb region on chromosome 20q13.1 (ref. 2). Here, we narrowed the candidate region to 1.2 Mb containing seven genes. Mutations in one of these genes, SLC2A10, encoding the facilitative glucose transporter GLUT10, were identified in six ATS families. GLUT10 deficiency is associated with upregulation of the TGFbeta pathway in the arterial wall, a finding also observed in Loeys-Dietz syndrome, in which aortic aneurysms associate with arterial tortuosity. The identification of a glucose transporter gene responsible for altered arterial morphogenesis is notable in light of the previously suggested link between GLUT10 and type 2 diabetes. Our data could provide new insight on the mechanisms causing microangiopathic changes associated with diabetes and suggest that therapeutic compounds intervening with TGFbeta signaling represent a new treatment strategy.

Authors : Coucke Paul J , Willaert Andy , Wessels Marja W , Callewaert Bert , Zoppi Nicoletta , De Backer Julie , Fox Joyce E , Mancini Grazia M S , Kambouris Marios , Gardella Rita , Facchetti Fabio , Willems Patrick J , Forsyth Ramses , Dietz Harry C , Barlati Sergio , Colombi Marina , Loeys Bart , De Paepe Anne ,

Related products :

Catalog number Product name Quantity
29-941 SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose homeostasis.SLC2A10 is a member of the facilitative glucose transporter family 0.1 mg
GLUT10-1001AP Rabbit Affinity Purified Glucose Transporter GLUT10 Antibody 100
P-GLUT10 Rabbit Glucose Transporter GLUT10 Antibody Blocking Peptide 250
PC-GLUT10 Rabbit Glucose Transporter GLUT10 Antibody Positive Control 5 Applications
GLUT10-1001AP Rabbit Glucose Transporter GLUT10 Antibody 100
Glut10-1001AP Glucose Transporter Type 10 antibody WB control: PC-Glut10 Host: Rabbit Affinity purifed 100-150ul
Glut10-1001AP Glucose Transporter Type 10 antibody Antigenic peptide: P-Glut10 Host: Rabbit Affinity purifed 100ul
Glut10-1001AP Glucose Transporter Type 10 antibody Biotin Conjugates: Glut10-Biotin Host: Rabbit Affinity purifed 200ul
Glut10-1001AP Glucose Transporter Type 10 antibody FITC-conjugates: Glut10-FITC Host: Rabbit Affinity purifed 200ul
GLUT10-FITC Rabbit FITC-Conjugated Glucose Transporter GLUT10 Antibody 100
25-890 SLC2A9 is a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. SLC2A9 may play a role in the development an 0.05 mg
YF-PA26661 anti-Glucose Transporter GLUT10 50 ul
E0736Mo Mouse Glucose Transporter 10 (GLUT10)ELISA kit 48T
YHB0609Mo Mouse Glucose Transporter 10 (GLUT10)ELISA kit 48T
YHB0609Mo Mouse Glucose Transporter 10 (GLUT10)ELISA kit 96T
201-02-0737 Mouse Glucose Transporter 10(GLUT10)ELISA kit 96T
201-12-2215 Human Glucose Transporter 10(GLUT10)ELISA Kit 96T
QY-E01956 Human Glucose Transporter 10(GLUT10)ELISA Kit 96T
YF-MA19430 anti-Glucose Transporter GLUT10 (1E12) 100 ug
E0735Mo Mouse Glucose Transporter 10 (GLUT10)ELISA kit 48T
201-12-2215 Human Glucose Transporter 10 (GLUT10)ELISA kit 48T
201-12-2215 Human Glucose Transporter 10 (GLUT10)ELISA kit 96T
PC-Glut10 Glucose Transporter Type 10 antibody, WB control 100-150ul
YHB1342Hu Human Glucose Transporter 10 (GLUT10)ELISA kit 48T
YHB1342Hu Human Glucose Transporter 10 (GLUT10)ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur