Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17229681
Publication Date : //

An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.


Hepatitis C virus (HCV) is a positive-sense single-stranded RNA virus. NS5b is an RNA-dependent RNA polymerase that polymerizes the newly synthesized RNA. HCV likely uses host proteins for its replication, similar to other RNA viruses. To identify the cellular factors involved in HCV replication, we searched for cellular proteins that interact with the NS5b protein. HnRNP A1 and septin 6 proteins were identified by coimmunoprecipitation and yeast two-hybrid screening, respectively. Interestingly, septin 6 protein also interacts with hnRNP A1. Moreover, hnRNP A1 interacts with the 5'-nontranslated region (5' NTR) and the 3' NTR of HCV RNA containing the cis-acting elements required for replication. Knockdown of hnRNP A1 and overexpression of C-terminally truncated hnRNP A1 reduced HCV replication. In addition, knockdown of septin 6 and overexpression of N-terminally truncated septin 6 inhibited HCV replication. These results indicate that the host proteins hnRNP A1 and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions.

Authors : Kim Chon Saeng , Seol Su Kyoung , Song Ok-Kyu , Park Ji Hoon , Jang Sung Key ,

Related products :

Catalog number Product name Quantity
EIAAB34342 Homo sapiens,Human,REPA1,Replication factor A protein 1,Replication protein A 70 kDa DNA-binding subunit,RF-A protein 1,RP-A p70,RPA1,RPA70,Single-stranded DNA-binding protein
EIAAB34273 60 kDa origin-specific DNA-binding protein,60 kDa replication initiation region protein,ATT-binding protein,DHFR oribeta-binding protein RIP60,Homo sapiens,Human,REPIN1,Replication initiator 1,RIP60,Z
EIAAB34343 Mouse,Mus musculus,Replication factor A protein 1,Replication protein A 70 kDa DNA-binding subunit,RF-A protein 1,RP-A p70,Rpa1
EIAAB35658 Bos taurus,Bovine,Helix-destabilizing protein,Heterogeneous nuclear ribonucleoprotein A1,hnRNP A1,hnRNP core protein A1,HNRNPA1,HNRPA1,Single-strand RNA-binding protein,Unwinding protein 1,UP1
18-003-44203 Heterogeneous nuclear ribonucleoprotein Q - hnRNP Q; hnRNP-Q; Synaptotagmin-binding. cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protei 0.1 mg Protein A
20-373-85018 Heterogeneous nuclear ribonucleoprotein Q - hnRNP Q; hnRNP-Q; Synaptotagmin-binding. cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protei 0.1 ml
20-373-85047 Heterogeneous nuclear ribonucleoprotein Q - hnRNP Q; hnRNP-Q; Synaptotagmin-binding. cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protei 0.05 ml
18-003-44204 Heterogeneous nuclear ribonucleoprotein Q - hnRNP Q; hnRNP-Q; Synaptotagmin-binding. cytoplasmic RNA-interacting protein; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protei 0.1 mg Protein A
EIAAB35657 HDP,Helix-destabilizing protein,Heterogeneous nuclear ribonucleoprotein A1,hnRNP A1,hnRNP core protein A1,Hnrnpa1,Hnrpa1,Rat,Rattus norvegicus,Single-strand RNA-binding protein
EIAAB35655 Helix-destabilizing protein,Heterogeneous nuclear ribonucleoprotein A1,hnRNP A1,hnRNP core protein A1,HNRNPA1,HNRPA1,Homo sapiens,Human,Single-strand RNA-binding protein
EIAAB35656 Fli-2,HDP-1,Helix-destabilizing protein,Heterogeneous nuclear ribonucleoprotein A1,hnRNP A1,hnRNP core protein A1,Hnrnpa1,Hnrpa1,Mouse,Mus musculus,Single-strand-binding protein,Tis,Topoisomerase-inhi
EIAAB08105 C14orf135,FBP2,HCV F protein-binding protein 2,Hepatitis C virus F protein-binding protein 2,Homo sapiens,Human,Pecanex-like protein C14orf135
EIAAB34344 Chicken,Gallus gallus,RCJMB04_17l6,Replication factor A protein 1,Replication protein A 70 kDa DNA-binding subunit,RF-A protein 1,RP-A p70,RPA1
EIAAB34345 Homo sapiens,Human,REPA2,Replication factor A protein 2,Replication protein A 32 kDa subunit,Replication protein A 34 kDa subunit,RF-A protein 2,RP-A p32,RP-A p34,RPA2,RPA32,RPA34
EIAAB33721 hnRNP associated with lethal yellow protein,Maternally-expressed hnRNP C-related protein,Merc,Mouse,Mus musculus,Raly,RNA-binding protein Raly
20-372-60021 replication protein A1. 70kDa (RPA1) - Mouse monoclonal anti-human RPA1 antibody; RP-A; RF-A; Replication factor-A protein 1; Single-stranded DNA-binding protein; p70 Monoclonal 0.1 mg
EIAAB34346 Mouse,Mus musculus,Replication factor A protein 2,Replication protein A 32 kDa subunit,Replication protein A 34 kDa subunit,RF-A protein 2,RP-A p32,RP-A p34,Rpa2,Rpa34
EIAAB37714 Homo sapiens,Human,MDA9,MDA-9,Melanoma differentiation-associated protein 9,Pro-TGF-alpha cytoplasmic domain-interacting protein 18,Scaffold protein Pbp1,SDCBP,SYCL,Syndecan-binding protein 1,Syntenin
EIAAB33722 Autoantigen p542,Heterogeneous nuclear ribonucleoprotein C-like 2,hnRNP associated with lethal yellow protein homolog,hnRNP core protein C-like 2,HNRPCL2,Homo sapiens,Human,P542,RALY,RNA-binding prote
orb81569 Hepatitis Virus Combined protein The E.coli derived 70 kDa recombinant protein contains sequences from gene products (proteins) of the hepatitis virus (HCV) were scanned by using different PCR-based t 100
bs-0728P Peptides: HCV-HCBP1_ACY-3(Hepatitis C virus core-binding protein 1) Protein Length:12-25 amino acids. 200ug lyophilized
EIAAB34348 Homo sapiens,Human,REPA3,Replication factor A protein 3,Replication protein A 14 kDa subunit,RF-A protein 3,RP-A p14,RPA14,RPA3
EIAAB11611 Dnmbp,Dynamin-binding protein,Kiaa1010,Mouse,Mus musculus,Scaffold protein Tuba
EIAAB37715 Mouse,Mus musculus,Scaffold protein Pbp1,Sdcbp,Syndecan-binding protein 1,Syntenin-1
EIAAB11612 DNMBP,Dynamin-binding protein,Homo sapiens,Human,KIAA1010,Scaffold protein Tuba


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur