Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17286989
Publication Date : //

Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands.

A novel transduction pathway via which apoptosis of keratinocytes is regulated through nicotinic acetylcholine (ACh) receptors (nAChRs) has emerged in studies of secreted mammalian Ly6/urokinase plasminogen-type activator receptor-related protein-1 and-2 (SLURP-1 and SLURP-2, respectively). SLURP-1 reportedly binds to alpha7 nAChRs and enhances the amplitude of macroscopic currents induced by ACh, leading to facilitation of apoptosis, whereas SLURP-2 binds to alpha3 nAChRs and prevents apoptosis. These observations prompted us to test whether SLURPs are expressed in immune cells and are involved in the regulation of immune function. We initially used reverse transcription-polymerase chain reaction analysis to characterize the expression profiles of SLURP mRNAs in several murine tissues and organs. Although SLURP-1 mRNA was not expressed in the pancreas, all other tissues and organs tested, including spleen and thymus, expressed both SLURP-1 and SLURP-2 mRNAs. Expression of both mRNAs also was detected in T and B cells, bone marrow-derived dendritic cells (DCs) and macrophages. Moreover, as in keratinocytes, stimulation of MOLT-3 human leukemic T cells with recombinant human SLURP-1 evoked intracellular Ca(2+) signaling. These results suggest that both SLURP-1 and SLURP-2 are expressed in various immune cells and organs, and that not only ACh but also SLURPs may be involved in regulating lymphocyte function via nAChR-mediated pathways.

Authors : Moriwaki Yasuhiro , Yoshikawa Ken , Fukuda Hiromi , Fujii Yoshihito X , Misawa Hidemi , Kawashima Koichiro ,

Related products :

Catalog number Product name Quantity
EIAAB38706 Mouse,Mus musculus,Secreted Ly-6_uPAR-related protein 2,Slurp2,SLURP-2
EIAAB38704 Ars,ARS component B,Mouse,Mus musculus,Secreted Ly-6_uPAR-related protein 1,Slurp1,SLURP-1
EIAAB38707 Homo sapiens,Human,Secreted Ly-6_uPAR-related protein 2,SLURP2,SLURP-2,UNQ871_PRO1889
EIAAB38705 Anti-neoplastic urinary protein,ANUP,ARS,ARS component B,ARS(component B)-81_S,Homo sapiens,Human,Secreted Ly-6_uPAR-related protein 1,SLURP1,SLURP-1
31-096 The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Mutations in neuronal nicotinic acetylcholine recepto 0.1 mg
25-765 CLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and re 0.05 mg
20-272-190379 Nicotinic Acetylcholine Receptor beta - Mouse monoclonal [B3] to Nicotinic Acetylcholine Receptor beta Monoclonal 0.25 ml
18-272-195003 Nicotinic Acetylcholine Receptor alpha 7 - Rabbit polyclonal to Nicotinic Acetylcholine Receptor alpha 7 Polyclonal 0.1 mg
E02N0064 Rat nicotinic acetylcholine receptor 96 Tests/kit
18-003-43294 Neuronal acetylcholine receptor protein subunit alpha-9 - Nicotinic acetylcholine receptor subunit alpha 9; NACHR alpha 9 Polyclonal 0.05 mg Aff Pur
U0981r Rat nicotinic acetylcholine receptor CLIA KIT 96T
E08N0064 Canine nicotinic acetylcholine receptor 96 Tests/kit
E03N0064 Mouse nicotinic acetylcholine receptor 96 Tests/kit
E13N0064 Anserine nicotinic acetylcholine receptor 96 Tests/kit
E02N0064 Rat anti-nicotinic acetylcholine receptor 96 Tests/kit
E04N0064 Rabbit nicotinic acetylcholine receptor 96 Tests/kit
ER1175 Nicotinic Acetylcholine Receptor Elisa Kit 96T
E06N0064 Goat nicotinic acetylcholine receptor 96 Tests/kit
E0981r Rat nicotinic acetylcholine receptor ELISA Kit 96T
E05N0064 Guinea nicotinic acetylcholine receptor 96 Tests/kit
E07N0064 Porcine nicotinic acetylcholine receptor 96 Tests/kit
E01N0064 Human nicotinic acetylcholine receptor 96 Tests/kit
E11N0064 Bovine nicotinic acetylcholine receptor 96 Tests/kit
E02N0064 Rat Nicotinic acetylcholine receptor ELISA 96T/kit
E11N0064 Bovine anti-nicotinic acetylcholine receptor 96 Tests/kit


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur

Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur