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Pubmed ID :17495919
Publication Date : //

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.


We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.

Authors : Mikkelsen Tarjei S , Wakefield Matthew J , Aken Bronwen , Amemiya Chris T , Chang Jean L , Duke Shannon , Garber Manuel , Gentles Andrew J , Goodstadt Leo , Heger Andreas , Jurka Jerzy , Kamal Michael , Mauceli Evan , Searle Stephen M J , Sharpe Ted , Baker Michelle L , Batzer Mark A , Benos Panayiotis V , Belov Katherine , Clamp Michele , Cook April , Cuff James , Das Radhika , Davidow Lance , Deakin Janine E , Fazzari Melissa J , Glass Jacob L , Grabherr Manfred , Greally John M , Gu Wanjun , Hore Timothy A , Huttley Gavin A , Kleber Michael , Jirtle Randy L , Koina Edda , Lee Jeannie T , Mahony Shaun , Marra Marco A , Miller Robert D , Nicholls Robert D , Oda Mayumi , Papenfuss Anthony T , Parra Zuly E , Pollock David D , Ray David A , Schein Jacqueline E , Speed Terence P , Thompson Katherine , VandeBerg John L , Wade Claire M , Walker Jerilyn A , Waters Paul D , Webber Caleb , Weidman Jennifer R , Xie Xiaohui , Zody Michael C , , , Graves Jennifer A Marshall , Ponting Chris P , Breen Matthew , Samollow Paul B , Lander Eric S , Lindblad-Toh Kerstin ,

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