Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :17699586
Publication Date : //

Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae.


Autophagy is a highly conserved, degradative process in eukaryotic cells. The rapamycin-sensitive Tor kinase complex 1 (TORC1) has a major role in regulating induction of autophagy; however, the regulatory mechanisms are not fully understood. Here, we find that the protein kinase A (PKA) and Sch9 signaling pathways regulate autophagy cooperatively in yeast. Autophagy is induced in cells when PKA and Sch9 are simultaneously inactivated. Mutant alleles of these kinases bearing a mutation that confers sensitivity to the ATP-analogue inhibitor C3-1'-naphthyl-methyl PP1 revealed that autophagy was induced independently of effects on Tor kinase. The PKA-Sch9-mediated autophagy depends on the autophagy-related 1 kinase complex, which is also essential for TORC1-regulated autophagy, the transcription factors Msn2/4, and the Rim15 kinase. The present results suggest that autophagy is controlled by the signals from at least three partly separate nutrient-sensing pathways that include PKA, Sch9, and TORC1.

Authors : Yorimitsu Tomohiro , Zaman Shadia , Broach James R , Klionsky Daniel J ,

Related products :

Catalog number Product name Quantity
Y050783 Anti-SCH9(Serine_threonine-protein kinase SCH9) Antibody 100ug
26-696 ARL13B has an evolutionarily conserved role mediating cilia function in multiple organs. N and C domains of ARL13B cooperatively regulate its ciliary localization and that N domain-dependent self-asso 0.05 mg
SCH-8203-0050 RABBIT ANTI SACCHAROMYCES CEREVISIAE, Product Type Polyclonal Antibody, Specificity SACCHAROMYCES CEREVISIAE, Target Species Yeast, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, Applica 1 ml
8203-0050 RABBIT ANTI SACCHAROMYCES CEREVISIAE, Product Type Polyclonal Antibody, Specificity SACCHAROMYCES CEREVISIAE, Target Species Yeast, Host Rabbit, Format Purified, Isotypes Polyclonal IgG, Applica 1 ml
31-044 The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosac 0.1 mg
62-302 anti_Cdc37 (S. cerevisiae) antibody, rabbit serum Background Cdc37 was initially identified as a cell division cycle control protein of Saccharomyces cerevisiae (1) and was later found to have a much 100 ul
60B557 Polyclonal Antibodies: SCH9; Specificity: SCH9 ; Application: IHC 0.1mg
Y050783 Anti-SCH9Serine per threonine-protein kinase SCH9 antibody 250ug
31-029 CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, 0.1 mg
18-272-196784 Saccharomyces cerevisiae - Rabbit polyclonal to Saccharomyces cerevisiae Polyclonal 0.5 ml
18-272-196783 Saccharomyces cerevisiae - Rabbit polyclonal to Saccharomyces cerevisiae Polyclonal 0.2 ml
84604-16-0 Saccharomyces cerevisiae Saccharomyces 1g
HSP-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 10µg
hsp-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 10
hsp-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 1mg
hsp-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 50
HSP-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 1mg
HSP-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 50µg
RP-630 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 10 ug
10-663-45498 Saccharomyces cerevisiae Heat Shock Protein 104 (HSP-104) - N_A N_A 0.05 mg
10-663-45498 Saccharomyces cerevisiae Heat Shock Protein 104 (HSP-104) - N_A N_A 0.01 mg
10-663-45498 Saccharomyces cerevisiae Heat Shock Protein 104 (HSP-104) - N_A N_A 1 mg
RHS-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 10
hsp-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 HSP104 10
hsp-104 Recombinant Saccharomyces cerevisiae Heat Shock Protein 104 HSP104 1mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur