Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :18088087
Publication Date : 2008/02/01

Phosphoproteome of resting human platelets.


Beside their main physiological function in hemostasis, platelets are also highly involved in pathological processes, such as atherothrombosis and inflammation. During hemostasis, binding of adhesive substrates to tyrosine-kinase-linked adhesion receptors and/or soluble agonists to G-protein coupled receptors leads to a cascade of intracellular signaling processes based on substrate (de)phosphorylation. The same mechanisms are involved in platelet activation at sites of atherosclerotic plaque rupture, contributing to vessel occlusion and consequently to pathologic states, such as myocardial infarction, stroke, or peripheral artery disease. To gain a deeper insight into platelet function, we analyzed the phosphoproteome of resting platelets and identified 564 phosphorylation sites from more than 270 proteins, of which many have not been described in platelets before. Among those were several unknown potential protein kinase A (PKA) and protein kinase G (PKG) substrates. Because platelet inhibition is tightly regulated especially by PKA and PKG activity, these proteins may represent important new targets for cardiovascular research. Thus, our finding that GPIbalpha is phosphorylated at Ser603 in resting platelets may represent a novel mechanism for the regulation of one of the most important platelet receptor (GPIb-IX-V) mediated signaling pathways by PKA/PKG.

Authors : Zahedi René P , Lewandrowski Urs , Wiesner Julia , Wortelkamp Stefanie , Moebius Jan , Schütz Claudia , Walter Ulrich , Gambaryan Stepan , Sickmann Albert ,

Related products :

Catalog number Product name Quantity
orb82662 Human BAFFR protein BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells 1 mg
orb82813 Mouse SF20 protein Recombinant Mouse SF20 is a bone marrow stroma-derived growth factor. SF20 is expressed in bone marrow, spleen stroma cells, resting mononuclear cells, resting CD8+ and CD19+ cells 1 mg
cd20 50 HUMAN CELL SURFACE MOLECULES cd 20 pre,resting and activated B Cells 50 nm 2 ml
cd20 250 HUMAN CELL SURFACE MOLECULES cd 20 pre,resting and activated B Cells 250 nm 2 ml
SCH-7480-2004 SHEEP ANTI RABBIT PLATELETS, Product Type Polyclonal Antibody, Specificity PLATELETS, Target Species Rabbit, Host Sheep, Format Serum, Isotypes Polyclonal IgG, Applications E, Clone 1 ml
7480-2004 SHEEP ANTI RABBIT PLATELETS, Product Type Polyclonal Antibody, Specificity PLATELETS, Target Species Rabbit, Host Sheep, Format Serum, Isotypes Polyclonal IgG, Applications E, Clone 1 ml
orb82751 Human MIP3 protein MIP3_CCL23 is a CC chemokine that signals through the CCR1 receptor. MIP3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphoc 1 mg
YSRTMCA2174 raf_1, binds at Phos.serine 233 (NOT resting), Clone Roy_28_1, Rat anti_; WB 0.1 mg.
BMDV1102 CD37, B_Cell (resting), gp 40_52kD, Clone HH1, Mab anti_Human; frozen_NO paraffin 0.5 ml.
4356-20 PF 4, human platelets 20 μg
IPLA-WB4 Whole Blood:Human Platelets Unit
AK8973-0000 Human Platelets Inquire
AK9578-0000 Human Platelets Inquire
4356-1000 PF 4, human platelets 1 mg
4356-20 PF 4, human platelets proteins 20 μg
4356-1000 PF 4, human platelets proteins 1 mg
cd9 250 HUMAN CELL SURFACE MOLECULES cd 9 platelets, pre B,mono,endothelia,epithilia 250 nm 2 ml
cd9 50 HUMAN CELL SURFACE MOLECULES cd 9 platelets, pre B,mono,endothelia,epithilia 50 nm 2 ml
4356-1000 PF 4, human platelets PLF4 Human 1 mg
IPLA-WB4 Human Biologicals Whole Blood Human Platelets Unit
PG52412 GPIIbIIIa, Human Source Human platelets 0.5 mg
MD-11-0103 Mouse Anti-Human CD63_ gp53 (Activated Platelets) Antibodies 100 Tests
EIAAB44617 Mouse,Mus musculus,PTK-RL-18,Resting lymphocyte kinase,Rlk,Txk,Tyrosine-protein kinase TXK
CSB-EL018091HU Human phospholipase A2, group IIA (platelets, synovial fluid) (PLA2G2A) ELISA kit, Species Human, Sample Type serum, plasma 96T
AK9578 Human Platelets HUMAN CELLS Inquire


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur