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Pubmed ID :18234089
Publication Date : 2008/03/27

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins.


The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail. The Rad23 family of proteins is known to bind ubiquitinated proteins through its two ubiquitin-associated (UBA) domains, and may participate in the delivery of ubiquitinated proteins to the proteasome through docking via the Rad23 ubiquitin-like (UBL) domain.

Authors : Goh Amanda M , Walters Kylie J , Elsasser Suzanne , Verma Rati , Deshaies Raymond J , Finley Daniel , Howley Peter M ,

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