Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :18509043
Publication Date : //

GPR56 regulates pial basement membrane integrity and cortical lamination.

GPR56 is a member of the family of adhesion G-protein-coupled receptors that have a large extracellular region containing a GPS (G-protein proteolytic site) domain. Loss-of-function mutations in the GPR56 gene cause a specific human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). BFPP is a radiological diagnosis and its histopathology remains unclear. This study demonstrates that loss of the mouse Gpr56 gene leads to neuronal ectopia in the cerebral cortex, a cobblestone-like cortical malformation. There are four crucial events in the development of cobblestone cortex, namely defective pial basement membrane (BM), abnormal anchorage of radial glial endfeet, mislocalized Cajal-Retzius cells, and neuronal overmigration. By detailed time course analysis, we reveal that the leading causal events are likely the breaches in the pial BM. We show further that GPR56 is present in abundance in radial glial endfeet. Furthermore, a putative ligand of GPR56 is localized in the marginal zone or overlying extracellular matrix. These observations provide compelling evidence that GPR56 functions in regulating pial BM integrity during cortical development.

Authors : Li Shihong , Jin Zhaohui , Koirala Samir , Bu Lihong , Xu Lei , Hynes Richard O , Walsh Christopher A , Corfas Gabriel , Piao Xianhua ,

Related products :

Catalog number Product name Quantity
MS620 Mitochondria Membrane Integrity Kit 255 µg
MS620 Mitochondria Membrane Integrity Kit 255 µg
31-376 FKTN regulates the migration and assembly of neurons during cortical histogenesis. Fukuyama congenital muscular dystrophy results from mutations in its gene. 0.1 mg
30-153 PEX3 is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, it is necessary for the import of 0.1 mg
RP17238760001 Glomerular Basement Membrane 1 mg
RP17238730005 Glomerular Basement Membrane 5 µg
RP17238730020 Glomerular Basement Membrane 20 µg
JSK-1 Jones Stain Kit (For Basement Membrane) 1 kit(s)
JSK-1 Jones Stain Kit (For Basement Membrane) 1 kit(s)
25-622 Synaptojanin 1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membra 0.05 mg
E02E0121 Rat epidermal basement membrane zone 96 Tests/kit
E02T0507 Rat tubular basement membrane antibody 96 Tests/kit
E02G0310 Rat glomerular basement membrane antibody 96 Tests/kit
AG19500 Basement Membrane Extract (human) (1.0 ml).
RP-841 Recombinant Human Glomerular Basement Membrane 5 ug
AG19500 Basement Membrane Extract (human) (1.0 ml). 1
E02T0507 Rat Tubular basement membrane antibody ELISA, TBM
E07E0121 Porcine epidermal basement membrane zone 96 Tests/kit
E03T0507 Mouse tubular basement membrane antibody 96 Tests/kit
E03G0310 Mouse glomerular basement membrane antibody 96 Tests/kit
E08T0507 Canine tubular basement membrane antibody 96 Tests/kit
E04E0121 Rabbit epidermal basement membrane zone 96 Tests/kit
E04G0310 Rabbit glomerular basement membrane antibody 96 Tests/kit
E05G0310 Guinea glomerular basement membrane antibody 96 Tests/kit
E12411950 Rat tubular basement membrane antibogy(TBM) ELISA KIT 1


GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur

Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur



9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017


france@gentaur.com | Gentaur

Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123

GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U

spain@gentaur.com | Gentaur

ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636

GENTAUR Poland Sp. z o.o.

ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556


Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur