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Pubmed ID :18515411
Publication Date : //

Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.


MUTYH-associated polyposis (MAP) is a recessive trait characterised by multiple colorectal adenomas and a high risk of colorectal cancer. MUTYH functions in the DNA base excision repair pathway and has a key role in the repair of oxidative DNA damage.

Authors : Dallosso A R , Dolwani S , Jones N , Jones S , Colley J , Maynard J , Idziaszczyk S , Humphreys V , Arnold J , Donaldson A , Eccles D , Ellis A , Evans D G , Frayling I M , Hes F J , Houlston R S , Maher E R , Nielsen M , Parry S , Tyler E , Moskvina V , Cheadle J P , Sampson J R ,

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