Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Publication Date : //
Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about 13,000 adults in the United States each year. The treatment of this disease has changed little in the past two decades, because most of the genetic events that initiate the disease remain undiscovered. Whole-genome sequencing is now possible at a reasonable cost and timeframe to use this approach for the unbiased discovery of tumour-specific somatic mutations that alter the protein-coding genes. Here we present the results obtained from sequencing a typical acute myeloid leukaemia genome, and its matched normal counterpart obtained from the same patient's skin. We discovered ten genes with acquired mutations; two were previously described mutations that are thought to contribute to tumour progression, and eight were new mutations present in virtually all tumour cells at presentation and relapse, the function of which is not yet known. Our study establishes whole-genome sequencing as an unbiased method for discovering cancer-initiating mutations in previously unidentified genes that may respond to targeted therapies.
Authors : Ley Timothy J , Mardis Elaine R , Ding Li , Fulton Bob , McLellan Michael D , Chen Ken , Dooling David , Dunford-Shore Brian H , McGrath Sean , Hickenbotham Matthew , Cook Lisa , Abbott Rachel , Larson David E , Koboldt Dan C , Pohl Craig , Smith Scott , Hawkins Amy , Abbott Scott , Locke Devin , Hillier Ladeana W , Miner Tracie , Fulton Lucinda , Magrini Vincent , Wylie Todd , Glasscock Jarret , Conyers Joshua , Sander Nathan , Shi Xiaoqi , Osborne John R , Minx Patrick , Gordon David , Chinwalla Asif , Zhao Yu , Ries Rhonda E , Payton Jacqueline E , Westervelt Peter , Tomasson Michael H , Watson Mark , Baty Jack , Ivanovich Jennifer , Heath Sharon , Shannon William D , Nagarajan Rakesh , Walter Matthew J , Link Daniel C , Graubert Timothy A , DiPersio John F , Wilson Richard K ,
Related products :
52062 Aachen Deutschland
Support Karolina Elandt
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
email@example.com | Gentaur | Gentaur
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Finland Helsset +358942419041
Magyarország Budapest +3619980547
US New York+17185132983
No related Items
Related Genes :
 Genetic heterogeneity of cytogenetically normal AML with mutations of .
 Expression of CD4 is correlated with an unfavorable prognosis in wild-type NPM1, FLT3-ITD-negative cytogenetically normal adult acute myeloid leukemia.
 Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia.
 Combination of RNA- and exome sequencing: Increasing specificity for identification of somatic point mutations and indels in acute leukaemia.
 DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
 Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia.
 Distribution of mutations in DNMT3A gene and the suitability of mutations in R882 codon for MRD monitoring in patients with AML.
 Let-7a-3 hypomethylation is associated with favorable/intermediate karyotypes but not with survival in acute myeloid leukemia.
 Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia.
 NPM1 gene mutation in Egyptian patients with cytogenetically normal acute myeloid leukemia.
Enter catalog number :