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Pubmed ID :19059915
Publication Date : //

Biosynthesis of prion protein nucleocytoplasmic isoforms by alternative initiation of translation.


The cellular prion protein PrP(C) is synthesized as a family of four distinct forms. Of these, (Cyt)PrP is a minor member that segregates outside of the secretory route and can generate cytotoxic forms. Using signal sequence mutants, we found that (Cyt)PrP is translated from a downstream AUG (coding for Met-8 in human PrP or Met-15 in Syrian hamster PrP). Shortening of the signal sequence dictated the spillage of this isoform into the cytosol, from where it accessed the nucleus or formed insoluble cytosolic aggregates if the proteasome is inhibited. The PrP isoform isolated from the nuclear fractions of cell and brain homogenates was partially SUMO-1-conjugated. Expression of HaPrP(M15) in cells caused an antiproliferative phenotype due to a cell cycle arrest at the G(0)/G(1) phase. The identification of this PrP isoform and its properties provides novel insight into PrP(C) physiological and pathological functions.

Authors : Juanes María E , Elvira Gema , García-Grande Aranzazu , Calero Miguel , Gasset María ,

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25-604 Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three su 0.05 mg
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25-607 This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine_threonine protein phosphatases and 0.05 mg
29-292 This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine_threonine protein phosphatases and 0.1 mg
29-415 This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine_threonine protein phosphatases and 0.1 mg
15-288-22403A Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg
15-288-22403A Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.05 mg
18-003-43602 Eukaryotic translation initiation factor 4E type 2 - eIF4E type 2; eIF-4E type 2; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg Protein A
10-288-22403F Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.1 mg
10-288-22403F Eukaryotic translation initiation factor 4E type 3 - eIF4E type 3; eIF-4E type 3; mRNA cap-binding protein type 3; Eukaryotic translation initiation factor 4E-like 3; Eukaryotic translation initiation 0.05 mg
EIAAB12726 eIF-3 p48,eIF3e,Eif3e,Eif3s6,Eukaryotic translation initiation factor 3 subunit 6,Eukaryotic translation initiation factor 3 subunit E,Int6,Mammary tumor-associated protein INT-6,MMTV integration site
26-291 EIF3E belongs to the eIF-3 subunit E family.It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthe 0.05 mg
25-619 EIF3G belongs to the eIF-3 subunit G family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synth 0.05 mg
EIAAB12755 EIF3EIP,eIF3l,EIF3L,EIF3S6IP,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein,Eukaryotic translation in
EIAAB12752 Bos taurus,Bovine,EIF3EIP,eIF3l,EIF3L,EIF3S6IP,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein,Eukaryo
EIAAB12703 65 kDa eukaryotic translation initiation factor 2A,CDA02,EIF2A,eIF-2A,Eukaryotic translation initiation factor 2A,Homo sapiens,Human,MSTP004,MSTP089
EIAAB12723 eIF-3 p48,eIF3e,EIF3E,EIF3S6,Eukaryotic translation initiation factor 3 subunit 6,Eukaryotic translation initiation factor 3 subunit E,Homo sapiens,Human,INT6,Viral integration site protein INT-6 homo
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EIAAB12749 ARG134,eIF-3 p25,eIF-3 p28,eIF3k,EIF3K,EIF3S12,Eukaryotic translation initiation factor 3 subunit 12,Eukaryotic translation initiation factor 3 subunit K,Homo sapiens,HSPC029,Human,MSTP001,Muscle-spec
EIAAB12700 eIF1b,EIF1B,Eukaryotic translation initiation factor 1b,Homo sapiens,Human,Protein translation factor SUI1 homolog GC20
EIAAB12702 eIF1b,EIF1B,Eukaryotic translation initiation factor 1b,Pig,Protein translation factor SUI1 homolog GC20,Sus scrofa
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