Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :19241384
Publication Date : //

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.


Acidic mammalian chitinase (AMCase) is a mammalian chitinase that has been implicated in allergic asthma. One of only two active mammalian chinases, AMCase, is distinguished from other chitinases by several unique features. Here, we present the novel structure of the AMCase catalytic domain, both in the apo form and in complex with the inhibitor methylallosamidin, determined to high resolution by X-ray crystallography. These results provide a structural basis for understanding some of the unique characteristics of this enzyme, including the low pH optimum and the preference for the beta-anomer of the substrate. A triad of polar residues in the second-shell is found to modulate the highly conserved chitinase active site. As a novel target for asthma therapy, structural details of AMCase activity will help guide the future design of specific and potent AMCase inhibitors.

Authors : Olland Andrea M , Strand James , Presman Eleonora , Czerwinski Robert , Joseph-McCarthy Diane , Krykbaev Rustem , Schlingmann Gerhard , Chopra Rajiv , Lin Laura , Fleming Margaret , Kriz Ron , Stahl Mark , Somers William , Fitz Lori , Mosyak Lidia ,

Related products :

Catalog number Product name Quantity
EM805 Acidic mammalian chitinase Elisa Kit 96T
EH2434 Acidic mammalian chitinase Elisa Kit 96T
CSB-EL005348RA Rat Acidic mammalian chitinase(CHIA) ELISA kit 96T
CSB-EL005348HU Human Acidic mammalian chitinase(CHIA) ELISA kit 96T
CSB-EL005348RA Rat Acidic mammalian chitinase(CHIA) ELISA kit SpeciesRat 96T
CSB-EL005348BO Bovine Acidic mammalian chitinase(CHIA) ELISA kit 96T
CSB-EL005348MO Mouse Acidic mammalian chitinase(CHIA) ELISA kit 96T
CSB-EL005348HU Human Acidic mammalian chitinase(CHIA) ELISA kit SpeciesHuman 96T
EIAAB07158 Acidic mammalian chitinase,AMCase,Chia,Rat,Rattus norvegicus
EIAAB07157 Acidic mammalian chitinase,AMCase,Chia,Mouse,Mus musculus,YNL
CSB-EL005348BO Bovine Acidic mammalian chitinase(CHIA) ELISA kit SpeciesBovine 96T
CSB-EL005348MO Mouse Acidic mammalian chitinase(CHIA) ELISA kit SpeciesMouse 96T
CHIA_BOVIN ELISA Kit FOR Acidic mammalian chitinase; organism: Bovine; gene name: CHIA 96T
EIAAB07155 Acidic mammalian chitinase,AMCase,Bos taurus,Bovine,CBPb04,CHIA,Chitin-binding protein b04
EIAAB07156 Acidic mammalian chitinase,AMCase,CHIA,Homo sapiens,Human,Lung-specific protein TSA1902
E13981h Human Chitinase, Acidic ELISA Kit 96T
CHIC2 CHIA Gene chitinase, acidic
201-12-3461 Human Chitinase, Acidic(CHIA)ELISA Kit 96T
QY-E01368 Human Chitinase, Acidic(CHIA)ELISA Kit 96T
UB-E01368 Human Chitinase, Acidic(CHIA)ELISA Kit 96T
CSB-EL005348RA Rat chitinase, acidic (CHIA) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL005348MO Mouse chitinase, acidic (CHIA) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL005348BO Bovine chitinase, acidic (CHIA) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL005348HU Human chitinase, acidic (CHIA) ELISA kit, Species Human, Sample Type serum, plasma 96T
27-413 PTF1A is a pancreas specific transcription factor. Mammalian studies have implicated important roles for the basic helix-loop-helix transcription factor PTF1A-p48 in the development of both exocrine a 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur