Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :19244510
Publication Date : //

TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons.


CREB-target gene transcription during neuronal excitation is important for many aspects of neuronal development and function, including dendrite morphogenesis. However, the signaling events that regulate cAMP response element-binding protein (CREB)-mediated gene transcription during dendritic development are not well understood. Herein we report that the CREB coactivator TORC1 (transducer of regulated CREB 1) is required for activity-dependent CREB-target gene expression and dendrite growth in developing cortical neurons. Ca(2+) influx via voltage-gated calcium channels induced TORC1 dephosphorylation and translocation into the nucleus in a calcineurin-dependent manner. Nuclear accumulation of TORC1 initiated the expression of CREB-target genes, including salt-inducible kinase 1 (SIK1). In response of persistent depolarization, de novo SIK1 protein in turn promoted TORC1 phosphorylation and consequent depletion of nucleus-localized TORC1. SIK1 induction thus appears to act as a negative feedback signal that prevents persistent CREB/TORC1-dependent transcription in the face of long-lasting neuronal activity. Overexpressing wild type TORC1 promoted basal as well as activity-induced dendritic growth, whereas expressing a dominant-negative form of TORC1 or downregulating TORC1 inhibited activity-dependent dendritic growth in vitro and in vivo. Together, these results suggest that neuronal activity-dependent dendritic growth in developing cortical neurons relies on transient TORC1-mediated CREB-target gene transcription.

Authors : Li Shuai , Zhang Chi , Takemori Hiroshi , Zhou Yang , Xiong Zhi-Qi ,

Related products :

Catalog number Product name Quantity
31-376 FKTN regulates the migration and assembly of neurons during cortical histogenesis. Fukuyama congenital muscular dystrophy results from mutations in its gene. 0.1 mg
EIAAB09455 CREB-regulated transcription coactivator 1,Crtc1,Kiaa0616,Mect1,Mouse,Mucoepidermoid carcinoma translocated protein 1 homolog,Mus musculus,Torc1,TORC-1,Transducer of CREB protein 1,Transducer of regul
EIAAB09454 CREB-regulated transcription coactivator 1,Crtc1,Mect1,Mucoepidermoid carcinoma translocated protein 1 homolog,Rat,Rattus norvegicus,Torc1,TORC-1,Transducer of CREB protein 1,Transducer of regulated c
EIAAB09453 CREB-regulated transcription coactivator 1,CRTC1,Homo sapiens,Human,KIAA0616,MECT1,Mucoepidermoid carcinoma translocated protein 1,TORC1,TORC-1,Transducer of CREB protein 1,Transducer of regulated cAM
PC35112 E18 Primary Mouse Cortical Neurons, 4 Cortical Pair 1
PC35112 E18 Primary Mouse Cortical Neurons, 4 Cortical Pair
4-20355 Neural Dissociation System 5 (Cortical Ganglion, retina Neurons, hippocampal Neurons, visual cortex), Mouse and Rat ea
27-359 TCFL5 is a new bHLH transcription factor that negatively regulates upstream transcription factor-dependent transcription. 0.05 mg
28-055 FREQ is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled rece 0.05 mg
  P-5009-CREB-96  QuantiSir Specific Gene Knockdown Quantification Kit For Transcription Factor _ CREB (96 assays)
P-5009-CREB-96 QuantiSir Specific Gene Knockdown Quantification Kit For Transcription Factor _ CREB 96 assays 96 assays
P-5009-CREB-96 QuantiSir Specific Gene Knockdown Quantification Kit For Transcription Factor - CREB (96 assays)
P10102 Rat Neurons-cortical 1 x 10A6 cells/vial
PC35117-2 E18 Rat Cortical Neurons Plated on 25 cm
PC35117-1 E18 Rat Cortical Neurons Plated on 25 cm
PC35117-3 E18 Rat Cortical Neurons Plated on 25 cm
25-664 POLDIP3 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. This gene encodes a protein that interacts wi 0.05 mg
PC35119-1 E18 Mouse Cortical Neurons Plated on 25 cm
18-783-76669 RABBIT ANTI HUMAN ADNP - ACTIVITY-DEPENDENT NEUROPROTECTOR; Activity-dependent neuroprotective protein Polyclonal 0.05 mg
27-490 NPAS1 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unc 0.05 mg
25-087 NPAS1 is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unc 0.05 mg
25-510 ZMIZ1 increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 0.05 mg
28-320 The PITX2 gene encodes a member of the RIEG_PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydr 0.1 mg
CRX CRTC3 Gene CREB regulated transcription coactivator 3
MEDCLA728 CD1a, Cortical Thymocyte, some X w_CD1b, Dendritic Cell, Clone MTB1, Mab anti_Human; frozen_paraffin 1 ml.


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur