Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Pubmed ID :20126385
Publication Date : //

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.


Wnt signalling pathways have extremely diverse functions in animals, including induction of cell fates or tumours, guidance of cell movements during gastrulation, and the induction of cell polarity. Wnt can induce polar changes in cellular morphology by a remodelling of the cytoskeleton. However, how activation of the Frizzled receptor induces cytoskeleton rearrangement is not well understood. We show, by an in depth 4-D microscopy analysis, that the Caenorhabditis elegans Wnt pathway signals to CED-10/Rac via two separate branches to regulate modulation of the cytoskeleton in different cellular situations. Apoptotic cell clearance and migration of the distal tip cell require the MOM-5/Fz receptor, GSK-3 kinase, and APC/APR-1, which activate the CED-2/5/12 branch of the engulfment machinery. MOM-5 (Frizzled) thus can function as an engulfment receptor in C. elegans. Our epistatic analyses also suggest that the two partially redundant signalling pathways defined earlier for engulfment may act in a single pathway in early embryos. By contrast, rearrangement of mitotic spindles requires the MOM-5/Fz receptor, GSK-3 kinase, and beta-catenins, but not the downstream factors LIT-1/NLK or POP-1/Tcf. Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton.

Authors : Cabello Juan , Neukomm Lukas J , Günesdogan Ufuk , Burkart Katharina , Charette Steve J , Lochnit Günter , Hengartner Michael O , Schnabel Ralf ,

Related products :

Catalog number Product name Quantity
25-791 ELMO3 is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins hav 0.05 mg
60409 Gli Reporter – NIH3T3 Cell line (Hedgehog Pathway),The Gli Reporter – NIH3T3 Cell Line is designed for monitoring the activity of the hedgehog signaling pathway. The hedgehog pathway controls stem cel 500 reactions
25-256 BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphor 0.05 mg
CS-1003-05 Frozen cell: miRNA Pathway Profiling Cell Array (Wnt_b-catenin Pathway, 8 Plates) 8 X 96
CS-1004-05 Frozen cell: miRNA Pathway Profiling Cell Array (Wnt_b-catenin Pathway, 4 Plates) 4 X 96
CS-1004-02 Frozen cell: miRNA Pathway Profiling Cell Array (NFkB Pathway, 4 Plates) 4 X 96
CS-1004-04 Frozen cell: miRNA Pathway Profiling Cell Array (MAPK_Ras Pathway, 4 Plates) 4 X 96
CS-1003-04 Frozen cell: miRNA Pathway Profiling Cell Array (MAPK_Ras Pathway, 8 Plates) 8 X 96
CS-1004-03 Frozen cell: miRNA Pathway Profiling Cell Array (Notch Pathway, 4 Plates) 4 X 96
CS-1004-01 Frozen cell: miRNA Pathway Profiling Cell Array (TGFb Pathway, 4 Plates) 4 X 96
CS-1003-01 Frozen cell: miRNA Pathway Profiling Cell Array (TGFb Pathway, 8 Plates) 8 X 96
CS-1003-03 Frozen cell: miRNA Pathway Profiling Cell Array (Notch Pathway, 8 Plates) 8 X 96
CS-1003-02 Frozen cell: miRNA Pathway Profiling Cell Array (NFkB Pathway, 8 Plates) 8 X 96
EIAAB07402 Cell death activator CIDE-B,Cell death-inducing DFFA-like effector B,Cideb,Mouse,Mus musculus
EIAAB07399 Cell death activator CIDE-A,Cell death-inducing DFFA-like effector A,Cidea,Mouse,Mus musculus
EIAAB07400 Bos taurus,Bovine,Cell death activator CIDE-B,Cell death-inducing DFFA-like effector B,CIDEB
EIAAB07398 Cell death activator CIDE-A,Cell death-inducing DFFA-like effector A,CIDEA,Homo sapiens,Human
EIAAB07401 Cell death activator CIDE-B,Cell death-inducing DFFA-like effector B,CIDEB,Homo sapiens,Human
18-661-15048 Cell death activator CIDE-A - Cell death-inducing DFFA-like effector A Polyclonal 0.1 mg
18-661-15049 Cell death activator CIDE-A - Cell death-inducing DFFA-like effector A Polyclonal 0.1 mg
18-661-15050 Cell death activator CIDE-B - Cell death-inducing DFFA-like effector B Polyclonal 0.1 mg
18-001-30077 Cell death activator CIDE-3 - Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27 homolog Polyclonal 0.1 mg
CS-1003-01 miRNA Pathway Profiling Cell Array (TGFb Pathway, 8 Plates) 8 X 96
CS-1004-05 miRNA Pathway Profiling Cell Array (Wnt b-catenin Pathway, 4 Plates) 4 X 96
CS-1004-04 miRNA Pathway Profiling Cell Array (MAPK Ras Pathway, 4 Plates) 4 X 96


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur